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• W2010218635 abstract "Objective: The potential for changing HIV-1 virulence has significant implications for the AIDS epidemic, including changing HIV transmission rates, rapidity of disease progression, and timing of ART. Published data to date have provided conflicting results. Design: We conducted a meta-analysis of changes in baseline CD4+ T-cell counts and set point plasma viral RNA load over time in order to establish whether summary trends are consistent with changing HIV-1 virulence. Methods: We searched PubMed for studies of trends in HIV-1 prognostic markers of disease progression and supplemented findings with publications referenced in epidemiological or virulence studies. We identified 12 studies of trends in baseline CD4+ T-cell counts (21 052 total individuals), and eight studies of trends in set point viral loads (10 785 total individuals), spanning the years 1984–2010. Using random-effects meta-analysis, we estimated summary effect sizes for trends in HIV-1 plasma viral loads and CD4+ T-cell counts. Results: Baseline CD4+ T-cell counts showed a summary trend of decreasing cell counts [effect = −4.93 cells/μl per year, 95% confidence interval (CI) −6.53 to −3.3]. Set point viral loads showed a summary trend of increasing plasma viral RNA loads (effect = 0.013 log10 copies/ml per year, 95% CI −0.001 to 0.03). The trend rates decelerated in recent years for both prognostic markers. Conclusion: Our results are consistent with increased virulence of HIV-1 over the course of the epidemic. Extrapolating over the 30 years since the first description of AIDS, this represents a CD4+ T cells loss of approximately 148 cells/μl and a gain of 0.39 log10 copies/ml of viral RNA measured during early infection. These effect sizes would predict increasing rates of disease progression, and need for ART as well as increasing transmission risk." @default.
• W2010218635 created "2016-06-24" @default.
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• W2010218635 date "2012-01-14" @default.
• W2010218635 modified "2023-10-02" @default.
• W2010218635 title "Is the virulence of HIV changing? A meta-analysis of trends in prognostic markers of HIV disease progression and transmission" @default.
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• W2010218635 doi "https://doi.org/10.1097/qad.0b013e32834db418" @default.
• W2010218635 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3597098" @default.
• W2010218635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22089381" @default.
• W2010218635 hasPublicationYear "2012" @default.
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