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- W2010225822 abstract "Many cargoes move bidirectionally, frequently reversing course between plus- and minus-end microtubule travel. For such cargoes, the extent and importance of interactions between the opposite-polarity motors is unknown. In this paper we test whether opposite-polarity motors on lipid droplets in Drosophila embryos are coordinated and avoid interfering with each other's activity, or whether they engage in a tug of war. To this end we impaired the minus-end transport machinery using dynein and dynactin mutations, and then investigated whether plus-end motion was improved or disrupted. We observe a surprisingly severe impairment of plus-end motion due to these alterations of minus-end motor activity. These observations are consistent with a coordination hypothesis, but cannot be easily explained with a tug of war model. Our measurements indicate that dynactin plays a crucial role in the coordination of plus- and minus-end-directed motors. Specifically, we propose that dynactin enables dynein to participate efficiently in bidirectional transport, increasing its ability to stay on during minus-end motion and keeping it off during plus-end motion." @default.
- W2010225822 created "2016-06-24" @default.
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- W2010225822 date "2002-02-28" @default.
- W2010225822 modified "2023-10-18" @default.
- W2010225822 title "Coordination of opposite-polarity microtubule motors" @default.
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- W2010225822 doi "https://doi.org/10.1083/jcb.200109047" @default.
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