Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010229505> ?p ?o ?g. }
- W2010229505 endingPage "1315" @default.
- W2010229505 startingPage "1304" @default.
- W2010229505 abstract "In endometriosis, stromal and epithelial cells from the endometrium form extrauterine lesions and persist in response to estrogen (E2) and prostaglandin E2 (PGE2). Stromal cells produce excessive quantities of estrogen and PGE2 in a feed-forward manner. However, it is unknown how estrogen stimulates cell proliferation and survival for the establishment and persistence of disease. Previous studies suggest that estrogen receptor-β (ERβ) is strikingly overexpressed in endometriotic stromal cells. Thus, we integrated genome-wide ERβ binding data from previously published studies in breast cells and gene expression profiles in human endometriosis and endometrial tissues (total sample number = 81) and identified Ras-like, estrogen-regulated, growth inhibitor (RERG) as an ERβ target. Estradiol potently induced RERG mRNA and protein levels in primary endometriotic stromal cells. Chromatin immunoprecipitation demonstrated E2-induced enrichment of ERβ at the RERG promoter region. PGE2 via protein kinase A phosphorylated RERG and enhanced the nuclear translocation of RERG. RERG induced the proliferation of primary endometriotic cells. Overall, we demonstrated that E2/ERβ and PGE2 integrate at RERG, leading to increased endometriotic cell proliferation and represents a novel candidate for therapeutic intervention." @default.
- W2010229505 created "2016-06-24" @default.
- W2010229505 creator A5005302652 @default.
- W2010229505 creator A5009298625 @default.
- W2010229505 creator A5014659826 @default.
- W2010229505 creator A5017170149 @default.
- W2010229505 creator A5024450756 @default.
- W2010229505 creator A5032268671 @default.
- W2010229505 creator A5039461728 @default.
- W2010229505 creator A5048896362 @default.
- W2010229505 creator A5052960883 @default.
- W2010229505 creator A5055679381 @default.
- W2010229505 creator A5057077440 @default.
- W2010229505 creator A5062738101 @default.
- W2010229505 creator A5065912386 @default.
- W2010229505 date "2014-08-01" @default.
- W2010229505 modified "2023-10-15" @default.
- W2010229505 title "ERβ- and Prostaglandin E2-Regulated Pathways Integrate Cell Proliferation via Ras-like and Estrogen-Regulated Growth Inhibitor in Endometriosis" @default.
- W2010229505 cites W1532292836 @default.
- W2010229505 cites W1666571513 @default.
- W2010229505 cites W1964279184 @default.
- W2010229505 cites W1965530278 @default.
- W2010229505 cites W1973817527 @default.
- W2010229505 cites W1975412389 @default.
- W2010229505 cites W1980912607 @default.
- W2010229505 cites W1982035170 @default.
- W2010229505 cites W1989622002 @default.
- W2010229505 cites W1989700964 @default.
- W2010229505 cites W1991931003 @default.
- W2010229505 cites W1995370499 @default.
- W2010229505 cites W2001306165 @default.
- W2010229505 cites W2003627629 @default.
- W2010229505 cites W2003847336 @default.
- W2010229505 cites W2028151572 @default.
- W2010229505 cites W2052591056 @default.
- W2010229505 cites W2057291577 @default.
- W2010229505 cites W2061369513 @default.
- W2010229505 cites W2066363077 @default.
- W2010229505 cites W2067099248 @default.
- W2010229505 cites W2069738597 @default.
- W2010229505 cites W2070294288 @default.
- W2010229505 cites W2074324848 @default.
- W2010229505 cites W2091204496 @default.
- W2010229505 cites W2099143842 @default.
- W2010229505 cites W2101163066 @default.
- W2010229505 cites W2103359602 @default.
- W2010229505 cites W2105455633 @default.
- W2010229505 cites W2106608030 @default.
- W2010229505 cites W2109367793 @default.
- W2010229505 cites W2113489193 @default.
- W2010229505 cites W2114245999 @default.
- W2010229505 cites W2116018335 @default.
- W2010229505 cites W2118388990 @default.
- W2010229505 cites W2121454015 @default.
- W2010229505 cites W2122475546 @default.
- W2010229505 cites W2143755503 @default.
- W2010229505 cites W2145057288 @default.
- W2010229505 cites W2147007332 @default.
- W2010229505 cites W2149541458 @default.
- W2010229505 cites W2154349377 @default.
- W2010229505 cites W2164434026 @default.
- W2010229505 cites W2166376600 @default.
- W2010229505 cites W2167536918 @default.
- W2010229505 cites W2169420807 @default.
- W2010229505 cites W2170725518 @default.
- W2010229505 cites W2171026981 @default.
- W2010229505 cites W4211081176 @default.
- W2010229505 cites W4231488642 @default.
- W2010229505 doi "https://doi.org/10.1210/me.2013-1421" @default.
- W2010229505 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4116594" @default.
- W2010229505 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24992181" @default.
- W2010229505 hasPublicationYear "2014" @default.
- W2010229505 type Work @default.
- W2010229505 sameAs 2010229505 @default.
- W2010229505 citedByCount "47" @default.
- W2010229505 countsByYear W20102295052015 @default.
- W2010229505 countsByYear W20102295052016 @default.
- W2010229505 countsByYear W20102295052017 @default.
- W2010229505 countsByYear W20102295052018 @default.
- W2010229505 countsByYear W20102295052019 @default.
- W2010229505 countsByYear W20102295052020 @default.
- W2010229505 countsByYear W20102295052021 @default.
- W2010229505 countsByYear W20102295052022 @default.
- W2010229505 countsByYear W20102295052023 @default.
- W2010229505 crossrefType "journal-article" @default.
- W2010229505 hasAuthorship W2010229505A5005302652 @default.
- W2010229505 hasAuthorship W2010229505A5009298625 @default.
- W2010229505 hasAuthorship W2010229505A5014659826 @default.
- W2010229505 hasAuthorship W2010229505A5017170149 @default.
- W2010229505 hasAuthorship W2010229505A5024450756 @default.
- W2010229505 hasAuthorship W2010229505A5032268671 @default.
- W2010229505 hasAuthorship W2010229505A5039461728 @default.
- W2010229505 hasAuthorship W2010229505A5048896362 @default.
- W2010229505 hasAuthorship W2010229505A5052960883 @default.
- W2010229505 hasAuthorship W2010229505A5055679381 @default.
- W2010229505 hasAuthorship W2010229505A5057077440 @default.
- W2010229505 hasAuthorship W2010229505A5062738101 @default.
- W2010229505 hasAuthorship W2010229505A5065912386 @default.