Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010239599> ?p ?o ?g. }
- W2010239599 endingPage "3088" @default.
- W2010239599 startingPage "3077" @default.
- W2010239599 abstract "Engagement of the antigen receptor on murine immature B cells leads to growth arrest followed by apoptosis. Concomitant signaling through CD40 sustains proliferation and rescues the cells from apoptosis. We show here that cross-linking CD40 stimulates the expression of A1, a member of the anti-apoptotic Bcl-2 family, in primary murine B lymphocytes. CD40-dependent stimulation of A1 was confirmed in WEHI 231 cells, an immature murine B cell lymphoma line. We transduced WEHI 231 cells with a bicistronic recombinant retroviral vector coding for A1 and a chimeric selection marker comprising the enhanced yellow fluorescent protein and the zeocin resistance protein. A1-transduced WEHI 231 cells showed a significant higher survival rate after engagement of the antigen receptor. In contrast, constitutive expression of A1 did not abrogate anti-IgM-induced c-myc down-regulation. Consistent with this, A1 did not release anti-IgM-induced cell cycle arrest. Our data indicate that CD40-stimulated A1 expression permits WEHI 231 cells to survive in the presence of anti-IgM antibodies and suggests a protective role for A1 in antigen receptor-mediated apoptosis in B cells." @default.
- W2010239599 created "2016-06-24" @default.
- W2010239599 creator A5026686208 @default.
- W2010239599 creator A5043126037 @default.
- W2010239599 creator A5056646573 @default.
- W2010239599 creator A5075495545 @default.
- W2010239599 creator A5088563693 @default.
- W2010239599 creator A5089689630 @default.
- W2010239599 date "1999-10-01" @default.
- W2010239599 modified "2023-10-03" @default.
- W2010239599 title "A1 expression is stimulated by CD40 in B cells and rescues WEHI 231 cells from anti-IgM-induced cell death" @default.
- W2010239599 cites W106241224 @default.
- W2010239599 cites W1497061219 @default.
- W2010239599 cites W1505818190 @default.
- W2010239599 cites W1524949022 @default.
- W2010239599 cites W1545309797 @default.
- W2010239599 cites W1554840117 @default.
- W2010239599 cites W1556216611 @default.
- W2010239599 cites W1575937211 @default.
- W2010239599 cites W1601529283 @default.
- W2010239599 cites W1882033673 @default.
- W2010239599 cites W1952068404 @default.
- W2010239599 cites W1964094843 @default.
- W2010239599 cites W1972201745 @default.
- W2010239599 cites W1982003581 @default.
- W2010239599 cites W1986801848 @default.
- W2010239599 cites W1988026284 @default.
- W2010239599 cites W1991304958 @default.
- W2010239599 cites W1997555839 @default.
- W2010239599 cites W1997946577 @default.
- W2010239599 cites W1998574404 @default.
- W2010239599 cites W2002507218 @default.
- W2010239599 cites W2007148405 @default.
- W2010239599 cites W2009014327 @default.
- W2010239599 cites W2017198560 @default.
- W2010239599 cites W2017521983 @default.
- W2010239599 cites W2030323895 @default.
- W2010239599 cites W2031778684 @default.
- W2010239599 cites W2038829679 @default.
- W2010239599 cites W2060382742 @default.
- W2010239599 cites W2061497413 @default.
- W2010239599 cites W2072930832 @default.
- W2010239599 cites W2074791128 @default.
- W2010239599 cites W2084260830 @default.
- W2010239599 cites W2089880838 @default.
- W2010239599 cites W2091085026 @default.
- W2010239599 cites W2094134866 @default.
- W2010239599 cites W2101577717 @default.
- W2010239599 cites W2105409819 @default.
- W2010239599 cites W2113999599 @default.
- W2010239599 cites W2124221273 @default.
- W2010239599 cites W2126909895 @default.
- W2010239599 cites W2135753091 @default.
- W2010239599 cites W2140646145 @default.
- W2010239599 cites W2141113110 @default.
- W2010239599 cites W2141454424 @default.
- W2010239599 cites W2141734513 @default.
- W2010239599 cites W2147153603 @default.
- W2010239599 cites W2154346380 @default.
- W2010239599 cites W2159219386 @default.
- W2010239599 cites W2160749209 @default.
- W2010239599 cites W2161102782 @default.
- W2010239599 cites W2165918134 @default.
- W2010239599 cites W2168703339 @default.
- W2010239599 cites W2328313834 @default.
- W2010239599 cites W2429778852 @default.
- W2010239599 cites W37150070 @default.
- W2010239599 cites W4237429324 @default.
- W2010239599 cites W4247158627 @default.
- W2010239599 doi "https://doi.org/10.1002/(sici)1521-4141(199910)29:10<3077::aid-immu3077>3.0.co;2-r" @default.
- W2010239599 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10540318" @default.
- W2010239599 hasPublicationYear "1999" @default.
- W2010239599 type Work @default.
- W2010239599 sameAs 2010239599 @default.
- W2010239599 citedByCount "82" @default.
- W2010239599 countsByYear W20102395992012 @default.
- W2010239599 countsByYear W20102395992013 @default.
- W2010239599 countsByYear W20102395992014 @default.
- W2010239599 countsByYear W20102395992015 @default.
- W2010239599 countsByYear W20102395992017 @default.
- W2010239599 countsByYear W20102395992019 @default.
- W2010239599 countsByYear W20102395992020 @default.
- W2010239599 countsByYear W20102395992021 @default.
- W2010239599 crossrefType "journal-article" @default.
- W2010239599 hasAuthorship W2010239599A5026686208 @default.
- W2010239599 hasAuthorship W2010239599A5043126037 @default.
- W2010239599 hasAuthorship W2010239599A5056646573 @default.
- W2010239599 hasAuthorship W2010239599A5075495545 @default.
- W2010239599 hasAuthorship W2010239599A5088563693 @default.
- W2010239599 hasAuthorship W2010239599A5089689630 @default.
- W2010239599 hasBestOaLocation W20102395991 @default.
- W2010239599 hasConcept C147483822 @default.
- W2010239599 hasConcept C153911025 @default.
- W2010239599 hasConcept C154317977 @default.
- W2010239599 hasConcept C159654299 @default.
- W2010239599 hasConcept C190283241 @default.
- W2010239599 hasConcept C19317047 @default.
- W2010239599 hasConcept C202751555 @default.