FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010242790> ?p ?o ?g. }

• W2010242790 endingPage "392" @default.
• W2010242790 startingPage "382" @default.
• W2010242790 abstract "Ectosomes are vesicles shed directly from the cell surface. Human polymorphonuclear neutrophils release ectosomes (PMN-Ect) upon their activation. PMN-Ect expose phosphatidylserine (PS) on the outer leaflet of the plasma membrane, and down-modulate the inflammatory response of human macrophages and dendritic cells exposed to TLR-2 and -4 ligands. This down-modulation is mediated by PS via the engagement and activation of the Mer receptor tyrosine kinase (MerTK). In the present study, we demonstrate that exposure of macrophages to PMN-Ect activates directly 2 additional pathways, an immediate Ca(2+) flux and a rapid release of TGF-β1. As expected, the Ca(2+) flux was necessary for the activation of TLR-2 pathway with the release of cytokines. However, MerTK blockade with antibodies did not modify the Ca(2+) flux, indicating an independent activation of Ca(2+) by PMN-Ect. Striking was that the rapid release of TGF-β1 was independent of the MerTK pathway and did not require a Ca(2+) flux. TGF-β1 was present in cytosolic storage pools, which were depleted after exposure of the macrophages to PMN-Ect, and no increase in TGF-β1 mRNA could be detected in the 3 first hours when maximal release had occurred. The release of TGF-β1 by macrophages was seen only for PMN-Ect and not for PS-liposomes or erythrocyte ectosomes, which express PS. However, blocking the PS of PMN-Ect inhibited TGF-β1 release, suggesting that PS expression was necessary although not sufficient for this release. Interestingly, the effects of PMN-Ect pre-exposure were lasting for 24h with the macrophages being less receptive to TLR-2 activation and TGF-β1 stores remaining low. In sum, PMN-Ect induce several signaling pathways in resting and stimulated macrophages, which include independently the MerTK pathway, Ca(2+) flux and the release of stored TGF-β1, and each might influence the immunomodulatory effects of macrophages." @default.
• W2010242790 created "2016-06-24" @default.
• W2010242790 creator A5012854160 @default.
• W2010242790 creator A5019019737 @default.
• W2010242790 creator A5025459897 @default.
• W2010242790 creator A5030835200 @default.
• W2010242790 creator A5078915790 @default.
• W2010242790 date "2013-03-01" @default.
• W2010242790 modified "2023-09-25" @default.
• W2010242790 title "Ectosomes of polymorphonuclear neutrophils activate multiple signaling pathways in macrophages" @default.
• W2010242790 cites W1480417935 @default.
• W2010242790 cites W1508394416 @default.
• W2010242790 cites W1599277155 @default.
• W2010242790 cites W1966830374 @default.
• W2010242790 cites W1969376664 @default.
• W2010242790 cites W1978588384 @default.
• W2010242790 cites W1986321004 @default.
• W2010242790 cites W1994426347 @default.
• W2010242790 cites W1996997447 @default.
• W2010242790 cites W2001695277 @default.
• W2010242790 cites W2019917125 @default.
• W2010242790 cites W2020716763 @default.
• W2010242790 cites W2021637137 @default.
• W2010242790 cites W2032331507 @default.
• W2010242790 cites W2033325645 @default.
• W2010242790 cites W2037758567 @default.
• W2010242790 cites W2037872626 @default.
• W2010242790 cites W2040481506 @default.
• W2010242790 cites W2043981736 @default.
• W2010242790 cites W2046758915 @default.
• W2010242790 cites W2058712031 @default.
• W2010242790 cites W2067883274 @default.
• W2010242790 cites W2086275775 @default.
• W2010242790 cites W2087226517 @default.
• W2010242790 cites W2095537212 @default.
• W2010242790 cites W2104180154 @default.
• W2010242790 cites W2113313714 @default.
• W2010242790 cites W2126662679 @default.
• W2010242790 cites W2131523916 @default.
• W2010242790 cites W2135327250 @default.
• W2010242790 cites W2142433114 @default.
• W2010242790 cites W2143193922 @default.
• W2010242790 cites W2149604782 @default.
• W2010242790 cites W2168568851 @default.
• W2010242790 cites W4235300003 @default.
• W2010242790 cites W4246506291 @default.
• W2010242790 cites W2088729275 @default.
• W2010242790 doi "https://doi.org/10.1016/j.imbio.2012.05.021" @default.
• W2010242790 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22749214" @default.
• W2010242790 hasPublicationYear "2013" @default.
• W2010242790 type Work @default.
• W2010242790 sameAs 2010242790 @default.
• W2010242790 citedByCount "65" @default.
• W2010242790 countsByYear W20102427902012 @default.
• W2010242790 countsByYear W20102427902013 @default.
• W2010242790 countsByYear W20102427902014 @default.
• W2010242790 countsByYear W20102427902015 @default.
• W2010242790 countsByYear W20102427902016 @default.
• W2010242790 countsByYear W20102427902017 @default.
• W2010242790 countsByYear W20102427902018 @default.
• W2010242790 countsByYear W20102427902019 @default.
• W2010242790 countsByYear W20102427902020 @default.
• W2010242790 countsByYear W20102427902021 @default.
• W2010242790 countsByYear W20102427902022 @default.
• W2010242790 countsByYear W20102427902023 @default.
• W2010242790 crossrefType "journal-article" @default.
• W2010242790 hasAuthorship W2010242790A5012854160 @default.
• W2010242790 hasAuthorship W2010242790A5019019737 @default.
• W2010242790 hasAuthorship W2010242790A5025459897 @default.
• W2010242790 hasAuthorship W2010242790A5030835200 @default.
• W2010242790 hasAuthorship W2010242790A5078915790 @default.
• W2010242790 hasConcept C101544691 @default.
• W2010242790 hasConcept C181199279 @default.
• W2010242790 hasConcept C185592680 @default.
• W2010242790 hasConcept C202751555 @default.
• W2010242790 hasConcept C2778918659 @default.
• W2010242790 hasConcept C2779244956 @default.
• W2010242790 hasConcept C2779637612 @default.
• W2010242790 hasConcept C2781185341 @default.
• W2010242790 hasConcept C41625074 @default.
• W2010242790 hasConcept C55493867 @default.
• W2010242790 hasConcept C62478195 @default.
• W2010242790 hasConcept C86803240 @default.
• W2010242790 hasConcept C95444343 @default.
• W2010242790 hasConcept C98539663 @default.
• W2010242790 hasConceptScore W2010242790C101544691 @default.
• W2010242790 hasConceptScore W2010242790C181199279 @default.
• W2010242790 hasConceptScore W2010242790C185592680 @default.
• W2010242790 hasConceptScore W2010242790C202751555 @default.
• W2010242790 hasConceptScore W2010242790C2778918659 @default.
• W2010242790 hasConceptScore W2010242790C2779244956 @default.
• W2010242790 hasConceptScore W2010242790C2779637612 @default.
• W2010242790 hasConceptScore W2010242790C2781185341 @default.
• W2010242790 hasConceptScore W2010242790C41625074 @default.
• W2010242790 hasConceptScore W2010242790C55493867 @default.
• W2010242790 hasConceptScore W2010242790C62478195 @default.
• W2010242790 hasConceptScore W2010242790C86803240 @default.
• W2010242790 hasConceptScore W2010242790C95444343 @default.

• next