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- W2010243434 abstract "Phospholipases A2 (PLA2s) belong to a superfamily of enzymes responsible for hydrolyzing the sn-2 fatty acids of membrane phospholipids. These enzymes are known to play multiple roles for maintenance of membrane phospholipid homeostasis and for production of a variety of lipid mediators. Over 20 different types of PLA2s are present in the mammalian cells, and in snake and bee venom. Despite their common function in hydrolyzing fatty acids of phospholipids, they are diversely encoded by a number of genes and express proteins that are regulated by different mechanisms. Recent studies have focused on the group IV calcium-dependent cytosolic cPLA2, the group VI calcium-independent iPLA2, and the group II small molecule secretory sPLA2. In the central nervous system (CNS), these PLA2s are distributed among neurons and glial cells. Although the physiological role of these PLA2s in regulating neural cell function has not yet been clearly elucidated, there is increasing evidence for their involvement in receptor signaling and transcriptional pathways that link oxidative events to inflammatory responses that underline many neurodegenerative diseases. Recent studies also reveal an important role of cPLA2 in modulating neuronal excitatory functions, sPLA2 in the inflammatory responses, and iPLA2 with childhood neurologic disorders associated with brain iron accumulation. The goal for this review is to better understand the structure and function of these PLA2s and to highlight specific types of PLA2s and their cross-talk mechanisms in these inflammatory responses under physiological and pathological conditions in the CNS." @default.
- W2010243434 created "2016-06-24" @default.
- W2010243434 creator A5026453991 @default.
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- W2010243434 creator A5088948223 @default.
- W2010243434 date "2009-10-24" @default.
- W2010243434 modified "2023-10-02" @default.
- W2010243434 title "Phospholipases A2 and Inflammatory Responses in the Central Nervous System" @default.
- W2010243434 cites W1511803494 @default.
- W2010243434 cites W1561713829 @default.
- W2010243434 cites W1573258040 @default.
- W2010243434 cites W1590150548 @default.
- W2010243434 cites W1964832799 @default.
- W2010243434 cites W1966629432 @default.
- W2010243434 cites W1970898912 @default.
- W2010243434 cites W1972581492 @default.
- W2010243434 cites W1973932627 @default.
- W2010243434 cites W1976477866 @default.
- W2010243434 cites W1977813572 @default.
- W2010243434 cites W1978659393 @default.
- W2010243434 cites W1980299884 @default.
- W2010243434 cites W1980358069 @default.
- W2010243434 cites W1982135509 @default.
- W2010243434 cites W1982250873 @default.
- W2010243434 cites W1984723429 @default.
- W2010243434 cites W1988861111 @default.
- W2010243434 cites W1989529271 @default.
- W2010243434 cites W1989720732 @default.
- W2010243434 cites W1989903509 @default.
- W2010243434 cites W1990948320 @default.
- W2010243434 cites W1992263834 @default.
- W2010243434 cites W1992569451 @default.
- W2010243434 cites W1992611170 @default.
- W2010243434 cites W1994395273 @default.
- W2010243434 cites W1994497941 @default.
- W2010243434 cites W1996870265 @default.
- W2010243434 cites W1997764369 @default.
- W2010243434 cites W1997940652 @default.
- W2010243434 cites W1998086227 @default.
- W2010243434 cites W1999045066 @default.
- W2010243434 cites W1999814935 @default.
- W2010243434 cites W2000162659 @default.
- W2010243434 cites W2001033348 @default.
- W2010243434 cites W2001429056 @default.
- W2010243434 cites W2002012958 @default.
- W2010243434 cites W2003196491 @default.
- W2010243434 cites W2003386154 @default.
- W2010243434 cites W2005787424 @default.
- W2010243434 cites W2007488351 @default.
- W2010243434 cites W2007715713 @default.
- W2010243434 cites W2007902074 @default.
- W2010243434 cites W2008270857 @default.
- W2010243434 cites W2010941033 @default.
- W2010243434 cites W2011197100 @default.
- W2010243434 cites W2015590789 @default.
- W2010243434 cites W2017563414 @default.
- W2010243434 cites W2019188478 @default.
- W2010243434 cites W2021124445 @default.
- W2010243434 cites W2024517044 @default.
- W2010243434 cites W2025209305 @default.
- W2010243434 cites W2025751875 @default.
- W2010243434 cites W2027349962 @default.
- W2010243434 cites W2028900907 @default.
- W2010243434 cites W2029253850 @default.
- W2010243434 cites W2031143643 @default.
- W2010243434 cites W2031181135 @default.
- W2010243434 cites W2032063742 @default.
- W2010243434 cites W2033035397 @default.
- W2010243434 cites W2033714165 @default.
- W2010243434 cites W2034904195 @default.
- W2010243434 cites W2036671631 @default.
- W2010243434 cites W2036843218 @default.
- W2010243434 cites W2037463313 @default.
- W2010243434 cites W2037508504 @default.
- W2010243434 cites W2038688567 @default.
- W2010243434 cites W2039524898 @default.
- W2010243434 cites W2039667137 @default.
- W2010243434 cites W2039802164 @default.
- W2010243434 cites W2040186280 @default.
- W2010243434 cites W2040804946 @default.
- W2010243434 cites W2041003777 @default.
- W2010243434 cites W2041600622 @default.
- W2010243434 cites W2042163079 @default.
- W2010243434 cites W2043634254 @default.
- W2010243434 cites W2044414978 @default.
- W2010243434 cites W2044474129 @default.
- W2010243434 cites W2045380216 @default.
- W2010243434 cites W2046031772 @default.
- W2010243434 cites W2046563296 @default.
- W2010243434 cites W2049830620 @default.
- W2010243434 cites W2050350946 @default.
- W2010243434 cites W2051966663 @default.
- W2010243434 cites W2052964034 @default.
- W2010243434 cites W2053606072 @default.
- W2010243434 cites W2054370762 @default.