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- W2010244903 abstract "Medical and Family History The 47-year old patient E.P. presented with multiple vertebral fractures to our osteologic out-patient clinic. In 1993 our patient had undergone gender reassignment surgery from male to female. Afterwards she had continuously been on hormone replacement therapy. In addition to vertebral fractures, the patient was suffering from a clinically stable colitis which was treated with mesalazine. The patient's mother is suffering from postmenopausal osteoporosis. Osteologic work-up: CTX were elevated (0,68 ng/ml). 25-(OH)-Vitamin D3 indicated a mild deficiency. All other relevant bone parameters were normal. DXA revealed low T-scores at all sites measured: Total hip -4,3/ lumbar spine -3,9. Via bone biopsy osteomalacia and malignant infiltration of the bone marrow could be excluded. Treatment: Based on the high levels of CTX, an antiresorptive treatment with intravenous ibandronate combined with calcium/vitamin D supplements was initiated. Discussion: In spite of significant endocrine interventions, bone health in transsexual individuals after gender reassignment therapy is rarely considered. The case highlights the need for investigations which closely monitor bone mass before, during and after gender reassignment therapy. In our patient we believe that a vulnerable genetic background (i.e. the positive familiy history) has been exposed to surgical (male) hypogonadism. Although the patient is receiving hormone replacement, therapy seemed to be insufficient to preserve bone health. In summary, we believe that since she has reached her peak bone mass as a man and therefore displays male bone geometry, female HRT cannot compensate for her skeleton's need for testosterone and estrogens together." @default.
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- W2010244903 date "2008-04-01" @default.
- W2010244903 modified "2023-09-22" @default.
- W2010244903 title "T04-O-04 Severe osteoporosis with multiple vertebral fractures after gender reassignment therapy – is it male or female osteoporosis?" @default.
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- W2010244903 doi "https://doi.org/10.1016/s1158-1360(08)72727-0" @default.
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