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- W2010251134 abstract "Purpose To compare the development of new renal damage in small children with dilating vesicoureteral reflux randomly allocated to antibiotic prophylaxis, endoscopic treatment or surveillance (control group). Material and Methods Included were 203 children, 128 girls and 75 boys, aged 1 to less than 2 years with reflux grade III to IV. Voiding cystourethrography and 99mTcdimercaptosuccinic acid scintigraphy were performed before randomization and after 2 years. Febrile urinary tract infections were recorded during the follow-up. Data analysis was performed according to the intention-to-treat principle. Results New renal damage in a previously unscarred area was seen in 15 children, 13 girls and 2 boys. Eight of these 13 girls were in the surveillance, 5 in the endoscopic, and none in the prophylaxis group (p=0.0155). New damage was seen more often in children with (11/49, 22%) than without (4/152, 3%) febrile recurrence (p Conclusions In boys the rate of new renal damage was low. It was significantly higher in girls, being most frequent in the surveillance (control) group. There was also a strong association between febrile UTI recurrence and development of new renal damage in girls." @default.
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- W2010251134 date "2010-04-01" @default.
- W2010251134 modified "2023-09-26" @default.
- W2010251134 title "Renal Damage in Children Randomized to Prophylaxis, Endoscopic Injection, or Surveillance – Results from the Swedish Reflux Trial" @default.
- W2010251134 doi "https://doi.org/10.1016/j.jpurol.2010.02.042" @default.
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