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- W2010256395 abstract "Hyperactivation of the enzyme, Cyclin Dependent Kinase Type II (CDK2) on binding with low molecular weight isoforms of its activator protein, Cyclin E has been reported in vivo. Such isoforms of Cyclin E are primarily detected in the nucleus of cancer cells. Here, we study the conformational variations of CDK2 complexed with various isoforms of Cyclin E, via Molecular Dynamics simulations. Results show significant energetic and structural changes in various key regions of the complexes including the substrate binding pocket of CDK2-Cyclin interface, Our results correlate very well with the data from experiments. The study could help designing specific inhibitors to target abnormal kinases." @default.
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- W2010256395 date "2012-01-01" @default.
- W2010256395 modified "2023-10-18" @default.
- W2010256395 title "The Structural Basis of Higher Activity of Truncated Cyclin E1-CDK2 Complexes in Tumor Cells" @default.
- W2010256395 doi "https://doi.org/10.1016/j.bpj.2011.11.2473" @default.
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