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• W2010256688 endingPage "119" @default.
• W2010256688 startingPage "101" @default.
• W2010256688 abstract "The distribution of D1 dopamine receptors was studied autoradiographically in the basal ganglia of the cat, monkey and human. These receptor binding sites were labeled directly with the D1-selective antagonist [3H]SCH 23390, and ligand-binding assays were performed concurrently. Serial- or same-action analysis permitted comparisons among D1 binding distributions, acetylcholinesterase staining and tyrosine hydroxylase immunoreactivity. In all species studied, the dorsal striatum exhibited patches of particularly dense D1 binding in correspondence with acetylcholinesterase-poor striosomes. Highly patterned binding was present in the ventral striatum. Distinctions in binding density were observed among the subdivisions of the globus pallidus and of the substantia nigra. The external segment of the pallidum was extremely sparse in D1 binding, whereas the internal segment (or entopeduncular nucleus in the cat) was a site of high D1 binding density. The binding density was greatest in the core of the internal segment, and tyrosine hydroxylase-positive fibers surrounded and weakly dispersed themselves through this core. Weak binding was present in the ventral pallidum. In the substantia nigra, the pars reticulata demonstrated the densest binding, particularly medially. The pars compacta showed much sparser binding, though some of its tyrosine hydroxylase-positive neurons had dendrites extending ventrally into the zone of dense D1 binding in the pars reticulata. We conclude that [3H]SCH 23390-defined D1 binding is compartmentalized in the dorsal striatum and that, particularly in relation to the reported distributions of striatal D2 dopamine receptors, this is likely to be of functional significance in the dopaminergic modulation of intrastriatal neurotransmission as well as of afferent and efferent neurotransmission. The segregated localizations of D1 receptors in the substantia nigra suggest predominant activation of the pars reticulata, including ventral and medial regions adjacent to the densocellular zone. Specific pathways from compartments in the striatum to subdivisions of the pallidum may also be differentially modulated by dopamine acting via distinct receptor subtypes. At the level of the pallidum, such D1 modulation appears to be restricted to the internal segment, which projects to the thalamus, rather than to the external pallidum, which projects to the subthalamic nucleus." @default.
• W2010256688 created "2016-06-24" @default.
• W2010256688 creator A5029154843 @default.
• W2010256688 creator A5081686751 @default.
• W2010256688 creator A5090757393 @default.
• W2010256688 date "1988-07-01" @default.
• W2010256688 modified "2023-09-23" @default.
• W2010256688 title "[3H]SCH 23390 binding to D1 dopamine receptors in the basal ganglia of the cat and primate: Delineation of striosomal compartments and pallidal and nigral subdivisions" @default.
• W2010256688 cites W1494064731 @default.
• W2010256688 cites W1501789797 @default.
• W2010256688 cites W1503918021 @default.
• W2010256688 cites W1506946474 @default.
• W2010256688 cites W1539309411 @default.
• W2010256688 cites W1556121655 @default.
• W2010256688 cites W1560939011 @default.
• W2010256688 cites W1592221471 @default.
• W2010256688 cites W1637481752 @default.
• W2010256688 cites W1643311486 @default.
• W2010256688 cites W1775749144 @default.
• W2010256688 cites W1884206649 @default.
• W2010256688 cites W1965335576 @default.
• W2010256688 cites W1967171661 @default.
• W2010256688 cites W1970251455 @default.
• W2010256688 cites W1972795403 @default.
• W2010256688 cites W1976045951 @default.
• W2010256688 cites W1978322449 @default.
• W2010256688 cites W1981988180 @default.
• W2010256688 cites W1988619576 @default.
• W2010256688 cites W1991583138 @default.
• W2010256688 cites W1992587213 @default.
• W2010256688 cites W1993140939 @default.
• W2010256688 cites W1995851628 @default.
• W2010256688 cites W1999095762 @default.
• W2010256688 cites W1999137262 @default.
• W2010256688 cites W2003342424 @default.
• W2010256688 cites W2004094484 @default.
• W2010256688 cites W2004930085 @default.
• W2010256688 cites W2005468531 @default.
• W2010256688 cites W2009579516 @default.
• W2010256688 cites W2011493269 @default.
• W2010256688 cites W2015366419 @default.
• W2010256688 cites W2015976856 @default.
• W2010256688 cites W2019501264 @default.
• W2010256688 cites W2021683549 @default.
• W2010256688 cites W2022649017 @default.
• W2010256688 cites W2024393284 @default.
• W2010256688 cites W2028050703 @default.
• W2010256688 cites W2030905853 @default.
• W2010256688 cites W2032551004 @default.
• W2010256688 cites W2036847153 @default.
• W2010256688 cites W2039035354 @default.
• W2010256688 cites W2039584565 @default.
• W2010256688 cites W2046302119 @default.
• W2010256688 cites W2047908143 @default.
• W2010256688 cites W2050580902 @default.
• W2010256688 cites W2051284638 @default.
• W2010256688 cites W2051877045 @default.
• W2010256688 cites W2052554533 @default.
• W2010256688 cites W2054610642 @default.
• W2010256688 cites W2057776879 @default.
• W2010256688 cites W2057788173 @default.
• W2010256688 cites W2062467837 @default.
• W2010256688 cites W2068020919 @default.
• W2010256688 cites W2069209764 @default.
• W2010256688 cites W2070340441 @default.
• W2010256688 cites W2070471777 @default.
• W2010256688 cites W2074040480 @default.
• W2010256688 cites W2079416717 @default.
• W2010256688 cites W2082139619 @default.
• W2010256688 cites W2085015621 @default.
• W2010256688 cites W2085622609 @default.
• W2010256688 cites W2088889438 @default.
• W2010256688 cites W2090677744 @default.
• W2010256688 cites W2091377586 @default.
• W2010256688 cites W2091516479 @default.
• W2010256688 cites W2092417393 @default.
• W2010256688 cites W2093352898 @default.
• W2010256688 cites W2103444004 @default.
• W2010256688 cites W2114722814 @default.
• W2010256688 cites W2119313744 @default.
• W2010256688 cites W2127087784 @default.
• W2010256688 cites W2164236172 @default.
• W2010256688 cites W3162876745 @default.
• W2010256688 doi "https://doi.org/10.1016/0306-4522(88)90130-3" @default.
• W2010256688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2901690" @default.
• W2010256688 hasPublicationYear "1988" @default.
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