Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010272826> ?p ?o ?g. }
- W2010272826 endingPage "1551" @default.
- W2010272826 startingPage "1545" @default.
- W2010272826 abstract "Laryngeal dysplasia is a common clinical concern. Despite major advancements, a significant number of patients with this condition progress to invasive squamous cell carcinoma. Osteopontin (OPN) is a secreted glycoprotein, whose expression is markedly elevated in several types of cancers. We explored OPN as a candidate biomarker for laryngeal dysplasia. To this aim, we examined OPN expression in 82 cases of dysplasia and in hyperplastic and normal tissue samples. OPN expression was elevated in all severe dysplasia samples, but not hyperplastic samples, with respect to matched normal mucosa. OPN expression levels correlated positively with degree of dysplasia (P=0.0094) and negatively with disease-free survival (P<0.0001). OPN expression was paralleled by cell surface reactivity for CD44v6, an OPN functional receptor. CD44v6 expression correlated negatively with disease-free survival, as well (P=0.0007). Taken as a whole, our finding identify OPN and CD44v6 as predictive markers of recurrence or aggressiveness in laryngeal intraepithelial neoplasia, and overall, point out an important signalling complex in the evolution of laryngeal dysplasia." @default.
- W2010272826 created "2016-06-24" @default.
- W2010272826 creator A5017757167 @default.
- W2010272826 creator A5021797078 @default.
- W2010272826 creator A5025377527 @default.
- W2010272826 creator A5027952276 @default.
- W2010272826 creator A5033522550 @default.
- W2010272826 creator A5047959368 @default.
- W2010272826 creator A5048101051 @default.
- W2010272826 creator A5048243012 @default.
- W2010272826 creator A5051690707 @default.
- W2010272826 creator A5061495027 @default.
- W2010272826 creator A5062770551 @default.
- W2010272826 creator A5068065146 @default.
- W2010272826 creator A5069912395 @default.
- W2010272826 creator A5070549842 @default.
- W2010272826 date "2007-11-06" @default.
- W2010272826 modified "2023-10-15" @default.
- W2010272826 title "OPN/CD44v6 overexpression in laryngeal dysplasia and correlation with clinical outcome" @default.
- W2010272826 cites W1492085907 @default.
- W2010272826 cites W1970179765 @default.
- W2010272826 cites W1971719458 @default.
- W2010272826 cites W1981017621 @default.
- W2010272826 cites W1986471913 @default.
- W2010272826 cites W2001258296 @default.
- W2010272826 cites W2003540668 @default.
- W2010272826 cites W2005204942 @default.
- W2010272826 cites W2007601283 @default.
- W2010272826 cites W2010703150 @default.
- W2010272826 cites W2023379322 @default.
- W2010272826 cites W2029455902 @default.
- W2010272826 cites W2033985429 @default.
- W2010272826 cites W2037632318 @default.
- W2010272826 cites W2046339703 @default.
- W2010272826 cites W2047902687 @default.
- W2010272826 cites W2052550299 @default.
- W2010272826 cites W2053574709 @default.
- W2010272826 cites W2057967714 @default.
- W2010272826 cites W2060339740 @default.
- W2010272826 cites W2068536063 @default.
- W2010272826 cites W2078942146 @default.
- W2010272826 cites W2086698289 @default.
- W2010272826 cites W2099269691 @default.
- W2010272826 cites W2099627769 @default.
- W2010272826 cites W2108197743 @default.
- W2010272826 cites W2117870131 @default.
- W2010272826 cites W2122012498 @default.
- W2010272826 cites W2122537519 @default.
- W2010272826 cites W2123995097 @default.
- W2010272826 cites W2132378346 @default.
- W2010272826 cites W2145261791 @default.
- W2010272826 cites W2153206163 @default.
- W2010272826 cites W2153397671 @default.
- W2010272826 cites W2157996654 @default.
- W2010272826 cites W2164202739 @default.
- W2010272826 cites W2170782044 @default.
- W2010272826 cites W2183959794 @default.
- W2010272826 cites W2406213538 @default.
- W2010272826 cites W2417702552 @default.
- W2010272826 doi "https://doi.org/10.1038/sj.bjc.6604070" @default.
- W2010272826 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2360266" @default.
- W2010272826 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17987038" @default.
- W2010272826 hasPublicationYear "2007" @default.
- W2010272826 type Work @default.
- W2010272826 sameAs 2010272826 @default.
- W2010272826 citedByCount "36" @default.
- W2010272826 countsByYear W20102728262012 @default.
- W2010272826 countsByYear W20102728262013 @default.
- W2010272826 countsByYear W20102728262014 @default.
- W2010272826 countsByYear W20102728262015 @default.
- W2010272826 countsByYear W20102728262016 @default.
- W2010272826 countsByYear W20102728262017 @default.
- W2010272826 countsByYear W20102728262018 @default.
- W2010272826 countsByYear W20102728262020 @default.
- W2010272826 countsByYear W20102728262021 @default.
- W2010272826 countsByYear W20102728262023 @default.
- W2010272826 crossrefType "journal-article" @default.
- W2010272826 hasAuthorship W2010272826A5017757167 @default.
- W2010272826 hasAuthorship W2010272826A5021797078 @default.
- W2010272826 hasAuthorship W2010272826A5025377527 @default.
- W2010272826 hasAuthorship W2010272826A5027952276 @default.
- W2010272826 hasAuthorship W2010272826A5033522550 @default.
- W2010272826 hasAuthorship W2010272826A5047959368 @default.
- W2010272826 hasAuthorship W2010272826A5048101051 @default.
- W2010272826 hasAuthorship W2010272826A5048243012 @default.
- W2010272826 hasAuthorship W2010272826A5051690707 @default.
- W2010272826 hasAuthorship W2010272826A5061495027 @default.
- W2010272826 hasAuthorship W2010272826A5062770551 @default.
- W2010272826 hasAuthorship W2010272826A5068065146 @default.
- W2010272826 hasAuthorship W2010272826A5069912395 @default.
- W2010272826 hasAuthorship W2010272826A5070549842 @default.
- W2010272826 hasBestOaLocation W20102728261 @default.
- W2010272826 hasConcept C121608353 @default.
- W2010272826 hasConcept C126322002 @default.
- W2010272826 hasConcept C142724271 @default.
- W2010272826 hasConcept C204232928 @default.
- W2010272826 hasConcept C2775894508 @default.
- W2010272826 hasConcept C2776235491 @default.