FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010275514> ?p ?o ?g. }

• W2010275514 endingPage "6103" @default.
• W2010275514 startingPage "6094" @default.
• W2010275514 abstract "In this article, the design and synthesis of some novel azasterols is described, followed by their evaluation against Trypanosoma brucei rhodesiense, T. cruzi, Leishmania donovani, and Plasmodium falciparum, the causative agents of human African trypanosomiasis, Chagas disease, leishmaniasis, and malaria, respectively. Some of the compounds showed anti-parasitic activity. In particular, a number of compounds appeared to very potently inhibit the growth of the blood stream form T. b. rhodesiense, with one compound giving an IC50 value of 12 nM. Clear structure activity relationships could be discerned. These compounds represent important leads for further optimization. Azasterols have previously been shown to inhibit sterol biosynthesis in T. cruzi and L. donovani by the inhibition of the enzyme sterol 24-methyltransferase. However, in this case, none of the compounds showed inhibition of the enzyme. Therefore, these compounds have an unknown mode of action." @default.
• W2010275514 created "2016-06-24" @default.
• W2010275514 creator A5032762018 @default.
• W2010275514 creator A5033358436 @default.
• W2010275514 creator A5046629806 @default.
• W2010275514 creator A5053604740 @default.
• W2010275514 creator A5053867182 @default.
• W2010275514 creator A5058960509 @default.
• W2010275514 creator A5065860171 @default.
• W2010275514 creator A5071065678 @default.
• W2010275514 creator A5072278846 @default.
• W2010275514 creator A5079135962 @default.
• W2010275514 creator A5089322468 @default.
• W2010275514 date "2006-09-08" @default.
• W2010275514 modified "2023-10-05" @default.
• W2010275514 title "Evaluation of Azasterols as Anti-Parasitics" @default.
• W2010275514 cites W1576525527 @default.
• W2010275514 cites W1926759118 @default.
• W2010275514 cites W1969583685 @default.
• W2010275514 cites W1991898467 @default.
• W2010275514 cites W1995734836 @default.
• W2010275514 cites W2026552674 @default.
• W2010275514 cites W2030381856 @default.
• W2010275514 cites W2033455856 @default.
• W2010275514 cites W2041642208 @default.
• W2010275514 cites W2044049361 @default.
• W2010275514 cites W2051660629 @default.
• W2010275514 cites W2055209578 @default.
• W2010275514 cites W2072737334 @default.
• W2010275514 cites W2073112650 @default.
• W2010275514 cites W2078173288 @default.
• W2010275514 cites W2105668259 @default.
• W2010275514 cites W2157236463 @default.
• W2010275514 cites W2160941302 @default.
• W2010275514 cites W2169613959 @default.
• W2010275514 cites W2171765967 @default.
• W2010275514 cites W2203917792 @default.
• W2010275514 cites W2333642805 @default.
• W2010275514 cites W4211252435 @default.
• W2010275514 cites W4243139710 @default.
• W2010275514 cites W4292671502 @default.
• W2010275514 cites W4299547134 @default.
• W2010275514 doi "https://doi.org/10.1021/jm060290f" @default.
• W2010275514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17004723" @default.
• W2010275514 hasPublicationYear "2006" @default.
• W2010275514 type Work @default.
• W2010275514 sameAs 2010275514 @default.
• W2010275514 citedByCount "59" @default.
• W2010275514 countsByYear W20102755142012 @default.
• W2010275514 countsByYear W20102755142013 @default.
• W2010275514 countsByYear W20102755142014 @default.
• W2010275514 countsByYear W20102755142015 @default.
• W2010275514 countsByYear W20102755142016 @default.
• W2010275514 countsByYear W20102755142017 @default.
• W2010275514 countsByYear W20102755142018 @default.
• W2010275514 countsByYear W20102755142020 @default.
• W2010275514 countsByYear W20102755142021 @default.
• W2010275514 countsByYear W20102755142023 @default.
• W2010275514 crossrefType "journal-article" @default.
• W2010275514 hasAuthorship W2010275514A5032762018 @default.
• W2010275514 hasAuthorship W2010275514A5033358436 @default.
• W2010275514 hasAuthorship W2010275514A5046629806 @default.
• W2010275514 hasAuthorship W2010275514A5053604740 @default.
• W2010275514 hasAuthorship W2010275514A5053867182 @default.
• W2010275514 hasAuthorship W2010275514A5058960509 @default.
• W2010275514 hasAuthorship W2010275514A5065860171 @default.
• W2010275514 hasAuthorship W2010275514A5071065678 @default.
• W2010275514 hasAuthorship W2010275514A5072278846 @default.
• W2010275514 hasAuthorship W2010275514A5079135962 @default.
• W2010275514 hasAuthorship W2010275514A5089322468 @default.
• W2010275514 hasConcept C104317684 @default.
• W2010275514 hasConcept C112418997 @default.
• W2010275514 hasConcept C121587506 @default.
• W2010275514 hasConcept C136764020 @default.
• W2010275514 hasConcept C159047783 @default.
• W2010275514 hasConcept C181199279 @default.
• W2010275514 hasConcept C185592680 @default.
• W2010275514 hasConcept C202751555 @default.
• W2010275514 hasConcept C203014093 @default.
• W2010275514 hasConcept C2776555147 @default.
• W2010275514 hasConcept C2777625466 @default.
• W2010275514 hasConcept C2777752497 @default.
• W2010275514 hasConcept C2778048844 @default.
• W2010275514 hasConcept C2778143080 @default.
• W2010275514 hasConcept C2778163477 @default.
• W2010275514 hasConcept C2778371730 @default.
• W2010275514 hasConcept C2778689377 @default.
• W2010275514 hasConcept C2778718757 @default.
• W2010275514 hasConcept C2778792689 @default.
• W2010275514 hasConcept C2779502636 @default.
• W2010275514 hasConcept C2781092759 @default.
• W2010275514 hasConcept C2781333301 @default.
• W2010275514 hasConcept C2909346784 @default.
• W2010275514 hasConcept C41008148 @default.
• W2010275514 hasConcept C55493867 @default.
• W2010275514 hasConcept C71928629 @default.
• W2010275514 hasConcept C86803240 @default.
• W2010275514 hasConcept C98274493 @default.

• next