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• W2010277767 abstract "Unlike ribose chemistry, the chemistry of 2-deoxyribose precludes its formation or at least its incorporation into nucleotides under accepted primordial soup conditions; therefore RNA and DNA could not develop in parallel during the evolution of protocells. However, deoxyribonucleotides might have been formed abiotically by direct reduction of ribonucleotides in a primitive version of the biochemical pathway. This sequence of events, in which DNA lagged behind RNA in the assembly of genetic information for an unknown--probably short--period of time is suggested by the primitive traits (i.e., nucleotide binding, thiol redox chemistry, and metal ion catalysis) of present-day enzyme systems of deoxyribonucleotide biosynthesis. The reaction should be amenable to experimental study." @default.
• W2010277767 created "2016-06-24" @default.
• W2010277767 creator A5072257719 @default.
• W2010277767 date "1986-01-01" @default.
• W2010277767 modified "2023-09-27" @default.
• W2010277767 title "Have deoxyribonucleotides and DNA been among the earliest biomolecules?" @default.
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• W2010277767 doi "https://doi.org/10.1016/0273-1177(86)90272-3" @default.
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