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• W2010277940 abstract "We recently observed a 25-fold increase in the activity of ornithine decarboxylase (ODC) 6 h after treatment of G1-synchronized CTLL-2 cells with interleukin-2 (IL-2). Here we show that the ODC mRNA content increased in parallel with the ODC activity during the first hours of stimulation with IL-2, resulting in a 25-fold increase at 6 h. Between 6 and 24 h the ODC mRNA content continued to increase steadily up to 50-fold, even after the ODC activity had returned to low basal levels. In the case of density-arrested CTLL-2 cells deprived of IL-2 for 16 h, the IL-2-mediated increase in ODC mRNA was 2-fold at 1 h and 5-fold at 8 h, irrespective of the capability of the cells to resume their cycle. There was no marked increase in the rate of transcription of the ODC gene, at least during the first 2 h of stimulation with IL-2. These findings suggest that the regulation of the ODC activity by IL-2 is a primary event in IL-2-induced cell proliferation and occurs at the post-transcriptional level, possibly by stabilizing the ODC mRNA and affecting the efficiency of translation of the messenger." @default.
• W2010277940 created "2016-06-24" @default.
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• W2010277940 date "1989-03-01" @default.
• W2010277940 modified "2023-10-18" @default.
• W2010277940 title "Interleukin-2 induces a rapid increase in ornithine decarboxylase mRNA in a cloned murine T lymphocytic cell line" @default.
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• W2010277940 doi "https://doi.org/10.1016/0014-4827(89)90201-2" @default.
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