Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010280862> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2010280862 endingPage "159" @default.
- W2010280862 startingPage "155" @default.
- W2010280862 abstract "To investigate the anti-tumor effect of bufalin and its regulation on Bcl-2 and Bax proteins in orthotopically transplanted tumor of human hepatocellular carcinoma in nude mice.Orthotopically transplanted tumor of human hepatocellular carcinoma was established in nude mice. The mice were randomly divided into five groups: high-dose bufalin-treated group (1.5 mg/kg), medium-dose bufalin-treated group (1 mg/kg), low-dose bufalin-treated group (0.5 mg/kg), adriamycin-treated group (8.0 mg/kg), and normal saline-treated group. After 25 days, mice were sacrificed. The tumor volume was measured, and the pathological changes of tumor tissues were detected by HE staining to observe the tumor necrosis degree. Cell morphological changes were also observed by an electron microscopy. Label index of tumor cell apoptosis was assessed by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL), and the expressions of Bcl-2 and Bax proteins were determined by immunohistochemical method.The tumor volume in the bufalin-treated groups was shrunk significantly compared with that in the normal saline-treated group (P<0.01). The survival time of the bufalin-treated groups was prolonged compared with that of the adriamycin-treated group and the normal saline-treated group P<0.05. Apoptotic characteristics could be seen in tumor tissues of the bufalin-treated groups. The label index of tumor cell apoptosis in the bufalin-treated groups (5.87+/-2.13, 8.86+/-2.96 and 10.60+/-3.42 in low-, medium- and high-dose groups respectively) was higher than that in the adriamycin-treated group (3.28+/-0.98) (P<0.05, P<0.01). The expression of Bax was up-regulated, while no changes were detected as to Bcl-2 protein in tumors of the bufalin-treated groups.Bufalin has significant anti-tumor effect on the orthotopically transplanted tumor of human hepatocellular carcinoma in nude mice. Its effect might be related to up-regulation of Bax protein and inducement of the tumor cell apoptosis." @default.
- W2010280862 created "2016-06-24" @default.
- W2010280862 creator A5062996178 @default.
- W2010280862 date "2007-03-15" @default.
- W2010280862 modified "2023-09-22" @default.
- W2010280862 title "Inhibition action of bufalin on human transplanted hepatocellular tumor and its effects on expressions of Bcl-2 and Bax proteins in nude mice" @default.
- W2010280862 cites W1969062050 @default.
- W2010280862 cites W1971183183 @default.
- W2010280862 cites W2004661120 @default.
- W2010280862 cites W2019468523 @default.
- W2010280862 cites W2031517092 @default.
- W2010280862 cites W2048719138 @default.
- W2010280862 cites W2053615546 @default.
- W2010280862 cites W2055060001 @default.
- W2010280862 doi "https://doi.org/10.3736/jcim20070211" @default.
- W2010280862 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17352871" @default.
- W2010280862 hasPublicationYear "2007" @default.
- W2010280862 type Work @default.
- W2010280862 sameAs 2010280862 @default.
- W2010280862 citedByCount "13" @default.
- W2010280862 countsByYear W20102808622012 @default.
- W2010280862 countsByYear W20102808622015 @default.
- W2010280862 countsByYear W20102808622016 @default.
- W2010280862 countsByYear W20102808622017 @default.
- W2010280862 countsByYear W20102808622018 @default.
- W2010280862 countsByYear W20102808622022 @default.
- W2010280862 crossrefType "journal-article" @default.
- W2010280862 hasAuthorship W2010280862A5062996178 @default.
- W2010280862 hasConcept C126322002 @default.
- W2010280862 hasConcept C142724271 @default.
- W2010280862 hasConcept C185592680 @default.
- W2010280862 hasConcept C190283241 @default.
- W2010280862 hasConcept C196795494 @default.
- W2010280862 hasConcept C204232928 @default.
- W2010280862 hasConcept C2777151579 @default.
- W2010280862 hasConcept C2777397205 @default.
- W2010280862 hasConcept C2778019345 @default.
- W2010280862 hasConcept C2780278673 @default.
- W2010280862 hasConcept C55493867 @default.
- W2010280862 hasConcept C71924100 @default.
- W2010280862 hasConceptScore W2010280862C126322002 @default.
- W2010280862 hasConceptScore W2010280862C142724271 @default.
- W2010280862 hasConceptScore W2010280862C185592680 @default.
- W2010280862 hasConceptScore W2010280862C190283241 @default.
- W2010280862 hasConceptScore W2010280862C196795494 @default.
- W2010280862 hasConceptScore W2010280862C204232928 @default.
- W2010280862 hasConceptScore W2010280862C2777151579 @default.
- W2010280862 hasConceptScore W2010280862C2777397205 @default.
- W2010280862 hasConceptScore W2010280862C2778019345 @default.
- W2010280862 hasConceptScore W2010280862C2780278673 @default.
- W2010280862 hasConceptScore W2010280862C55493867 @default.
- W2010280862 hasConceptScore W2010280862C71924100 @default.
- W2010280862 hasIssue "2" @default.
- W2010280862 hasLocation W20102808621 @default.
- W2010280862 hasLocation W20102808622 @default.
- W2010280862 hasOpenAccess W2010280862 @default.
- W2010280862 hasPrimaryLocation W20102808621 @default.
- W2010280862 hasRelatedWork W2010280862 @default.
- W2010280862 hasRelatedWork W2175626822 @default.
- W2010280862 hasRelatedWork W2350996322 @default.
- W2010280862 hasRelatedWork W2353736367 @default.
- W2010280862 hasRelatedWork W2373857529 @default.
- W2010280862 hasRelatedWork W2375665005 @default.
- W2010280862 hasRelatedWork W2376494150 @default.
- W2010280862 hasRelatedWork W2380423849 @default.
- W2010280862 hasRelatedWork W2388106672 @default.
- W2010280862 hasRelatedWork W2471058098 @default.
- W2010280862 hasVolume "5" @default.
- W2010280862 isParatext "false" @default.
- W2010280862 isRetracted "false" @default.
- W2010280862 magId "2010280862" @default.
- W2010280862 workType "article" @default.