Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010284073> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2010284073 endingPage "268" @default.
- W2010284073 startingPage "255" @default.
- W2010284073 abstract "The reactivity of monoclonal and polyclonal antibodies directed against human central nervous system (CNS) myelin-associated glycoprotein (MAG) was investigated in a number of animal species. The antibodies included mouse monoclonal antibodies obtained by immunization with human MAG; HNK-1, a mouse monoclonal antibody raised against a human lymphoblastoma and used to identify a subset of lymphocytes with natural killer function; human IgM paraproteins associated with neuropathy; and polyclonal antibodies obtained from rabbits immunized with rat or human MAG. Following polyacrylamide gel electrophoresis of CNS and peripheral nervous system (PNS) tissue from human, bovine, cat, rabbit, guinea pig, rat, mouse, frog, gold fish and chicken, proteins were electrophoretically transferred onto nitrocellulose. The immune-staining of electroblots showed distinct interspecies variation in the reactivity of the antibodies with MAG. In addition, the species distribution of several low molecular weight glycoproteins present in PNS tissue that cross-react with anti-MAG antibodies was determined. These low molecular weight antigens are not present in CNS homogenates or in purified human CNS myelin. It was also shown that IgM from a patient with peripheral neuropathy and paraproteinemia associated with anti-MAG antibodies recognized these low molecular weight antigens. The results suggest that IgM paraproteins, HNK-1 and some mouse monoclonal antibodies react with carbohydrate determinants shared by MAG and several lower molecular weight glycoproteins present only in human, bovine, cat and chicken PNS. Rabbit polyclonal anti-rat MAG antisera and mouse monoclonal antibodies reacting with peptide epitopes of MAG are much more specific for detecting MAG than antibodies reacting with carbohydrate epitopes of human MAG. The results are discussed in relation to human demyelinating peripheral neuropathy associated with IgM paraproteinemia." @default.
- W2010284073 created "2016-06-24" @default.
- W2010284073 creator A5000168044 @default.
- W2010284073 creator A5020942776 @default.
- W2010284073 creator A5030347733 @default.
- W2010284073 creator A5063443996 @default.
- W2010284073 creator A5076485365 @default.
- W2010284073 date "1985-01-01" @default.
- W2010284073 modified "2023-10-16" @default.
- W2010284073 title "The species distribution of nervous system antigens that react with anti-myelin-associated glycoprotein antibodies" @default.
- W2010284073 cites W1489850871 @default.
- W2010284073 cites W1775749144 @default.
- W2010284073 cites W1966039711 @default.
- W2010284073 cites W1966667541 @default.
- W2010284073 cites W1969563687 @default.
- W2010284073 cites W1970992620 @default.
- W2010284073 cites W1979246833 @default.
- W2010284073 cites W1981472848 @default.
- W2010284073 cites W1988580787 @default.
- W2010284073 cites W1990135103 @default.
- W2010284073 cites W1991258224 @default.
- W2010284073 cites W2000061301 @default.
- W2010284073 cites W2001623458 @default.
- W2010284073 cites W2016052374 @default.
- W2010284073 cites W2027134391 @default.
- W2010284073 cites W2073006349 @default.
- W2010284073 cites W2079108764 @default.
- W2010284073 cites W2090462321 @default.
- W2010284073 cites W2100837269 @default.
- W2010284073 cites W2119216843 @default.
- W2010284073 cites W2132744454 @default.
- W2010284073 cites W2160805055 @default.
- W2010284073 cites W2748938322 @default.
- W2010284073 cites W2768090954 @default.
- W2010284073 doi "https://doi.org/10.1016/s0165-5728(85)80024-2" @default.
- W2010284073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2410452" @default.
- W2010284073 hasPublicationYear "1985" @default.
- W2010284073 type Work @default.
- W2010284073 sameAs 2010284073 @default.
- W2010284073 citedByCount "75" @default.
- W2010284073 countsByYear W20102840732017 @default.
- W2010284073 crossrefType "journal-article" @default.
- W2010284073 hasAuthorship W2010284073A5000168044 @default.
- W2010284073 hasAuthorship W2010284073A5020942776 @default.
- W2010284073 hasAuthorship W2010284073A5030347733 @default.
- W2010284073 hasAuthorship W2010284073A5063443996 @default.
- W2010284073 hasAuthorship W2010284073A5076485365 @default.
- W2010284073 hasConcept C108625454 @default.
- W2010284073 hasConcept C147483822 @default.
- W2010284073 hasConcept C153911025 @default.
- W2010284073 hasConcept C159654299 @default.
- W2010284073 hasConcept C169760540 @default.
- W2010284073 hasConcept C195616568 @default.
- W2010284073 hasConcept C203014093 @default.
- W2010284073 hasConcept C2778609137 @default.
- W2010284073 hasConcept C529278444 @default.
- W2010284073 hasConcept C542903549 @default.
- W2010284073 hasConcept C8162170 @default.
- W2010284073 hasConcept C86803240 @default.
- W2010284073 hasConcept C91523082 @default.
- W2010284073 hasConcept C956191 @default.
- W2010284073 hasConceptScore W2010284073C108625454 @default.
- W2010284073 hasConceptScore W2010284073C147483822 @default.
- W2010284073 hasConceptScore W2010284073C153911025 @default.
- W2010284073 hasConceptScore W2010284073C159654299 @default.
- W2010284073 hasConceptScore W2010284073C169760540 @default.
- W2010284073 hasConceptScore W2010284073C195616568 @default.
- W2010284073 hasConceptScore W2010284073C203014093 @default.
- W2010284073 hasConceptScore W2010284073C2778609137 @default.
- W2010284073 hasConceptScore W2010284073C529278444 @default.
- W2010284073 hasConceptScore W2010284073C542903549 @default.
- W2010284073 hasConceptScore W2010284073C8162170 @default.
- W2010284073 hasConceptScore W2010284073C86803240 @default.
- W2010284073 hasConceptScore W2010284073C91523082 @default.
- W2010284073 hasConceptScore W2010284073C956191 @default.
- W2010284073 hasLocation W20102840731 @default.
- W2010284073 hasLocation W20102840732 @default.
- W2010284073 hasOpenAccess W2010284073 @default.
- W2010284073 hasPrimaryLocation W20102840731 @default.
- W2010284073 hasRelatedWork W1856187979 @default.
- W2010284073 hasRelatedWork W2025678534 @default.
- W2010284073 hasRelatedWork W2045337040 @default.
- W2010284073 hasRelatedWork W2057918160 @default.
- W2010284073 hasRelatedWork W2095527878 @default.
- W2010284073 hasRelatedWork W2146940419 @default.
- W2010284073 hasRelatedWork W2153679278 @default.
- W2010284073 hasRelatedWork W2386118910 @default.
- W2010284073 hasRelatedWork W4206011279 @default.
- W2010284073 hasRelatedWork W4239344034 @default.
- W2010284073 hasVolume "9" @default.
- W2010284073 isParatext "false" @default.
- W2010284073 isRetracted "false" @default.
- W2010284073 magId "2010284073" @default.
- W2010284073 workType "article" @default.