Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010291223> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2010291223 endingPage "2714" @default.
- W2010291223 startingPage "2710" @default.
- W2010291223 abstract "Introduction: Although thyroid hormone deficiency, either clinical or subclinical, is an established risk factor for cardiovascular disease, coronary ischemia in a premenopausal woman in her 30s is relatively rare. Case summary: A 38-year-old woman was referred to our hospital with severe breathlessness and depressed consciousness. Physical examination found facial, abdominal, and pretibial edema; coarse hair, hoarse voice, and dry skin; engorged jugular veins; a distant heart sound; and reduced bilateral entry of air into the chest. Laboratory examinations revealed severe hypothyroidism, hyperlipidemia, and elevated serum levels of carcinoembryonic antigen (CEA) and carbohydrate antigen 125 (CA125). A computed tomography scan showed massive pleural and pericardial effusions. After 3 months of levothyroxine replacement therapy (initial dose: 12.5 μg/d; maintenance dose: 125 μg/d), all abnormal laboratory values associated with hypothyroidism returned to within normal ranges, with the exception of a transient and paradoxical rise in serum thyroid-stimulating hormone levels. However, 3 weeks after the initiation of therapy, the patient reported intermittent chest pains during the course of therapy, and a coronary artery angiogram revealed diffuse stenosis of all 3 branches. The patient underwent coronary artery bypass grafting, with subsequent improvement in coronary perfusion. Discussion: Careful cardiovascular evaluation is recommended before the start of thyroid hormone replacement therapy. In addition, care should be taken in the interpretation of serum biomarkers of malignancy (eg, CEA, CA125) in patients with myxedema, as values may be elevated in a hypothyroid state. Conclusions: Long-standing hypothyroidism may be associated with severe coronary atherosclerosis, even in a relatively young, premenopausal woman. The potential adverse cardiovascular effects of thyroid hormone must be considered during replacement therapy, even in relatively young patients." @default.
- W2010291223 created "2016-06-24" @default.
- W2010291223 creator A5040292551 @default.
- W2010291223 creator A5045586814 @default.
- W2010291223 creator A5073976571 @default.
- W2010291223 creator A5078598537 @default.
- W2010291223 creator A5090425337 @default.
- W2010291223 date "2007-12-01" @default.
- W2010291223 modified "2023-10-14" @default.
- W2010291223 title "Myxedema coma and cardiac ischemia in relation to thyroid hormone replacement therapy in a 38-year-old Japanese woman" @default.
- W2010291223 cites W186187981 @default.
- W2010291223 cites W1995135039 @default.
- W2010291223 cites W1998194705 @default.
- W2010291223 cites W2013465892 @default.
- W2010291223 cites W2018880014 @default.
- W2010291223 cites W2057681305 @default.
- W2010291223 cites W2081799354 @default.
- W2010291223 cites W2086519212 @default.
- W2010291223 cites W2130567382 @default.
- W2010291223 cites W2137954871 @default.
- W2010291223 cites W2143573937 @default.
- W2010291223 cites W2325705904 @default.
- W2010291223 cites W2338942709 @default.
- W2010291223 doi "https://doi.org/10.1016/j.clinthera.2007.12.025" @default.
- W2010291223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18201588" @default.
- W2010291223 hasPublicationYear "2007" @default.
- W2010291223 type Work @default.
- W2010291223 sameAs 2010291223 @default.
- W2010291223 citedByCount "8" @default.
- W2010291223 countsByYear W20102912232016 @default.
- W2010291223 countsByYear W20102912232019 @default.
- W2010291223 crossrefType "journal-article" @default.
- W2010291223 hasAuthorship W2010291223A5040292551 @default.
- W2010291223 hasAuthorship W2010291223A5045586814 @default.
- W2010291223 hasAuthorship W2010291223A5073976571 @default.
- W2010291223 hasAuthorship W2010291223A5078598537 @default.
- W2010291223 hasAuthorship W2010291223A5090425337 @default.
- W2010291223 hasConcept C121608353 @default.
- W2010291223 hasConcept C126322002 @default.
- W2010291223 hasConcept C141071460 @default.
- W2010291223 hasConcept C164705383 @default.
- W2010291223 hasConcept C2775883008 @default.
- W2010291223 hasConcept C2777387746 @default.
- W2010291223 hasConcept C2780101021 @default.
- W2010291223 hasConcept C2780275930 @default.
- W2010291223 hasConcept C526584372 @default.
- W2010291223 hasConcept C530470458 @default.
- W2010291223 hasConcept C71924100 @default.
- W2010291223 hasConcept C90924648 @default.
- W2010291223 hasConceptScore W2010291223C121608353 @default.
- W2010291223 hasConceptScore W2010291223C126322002 @default.
- W2010291223 hasConceptScore W2010291223C141071460 @default.
- W2010291223 hasConceptScore W2010291223C164705383 @default.
- W2010291223 hasConceptScore W2010291223C2775883008 @default.
- W2010291223 hasConceptScore W2010291223C2777387746 @default.
- W2010291223 hasConceptScore W2010291223C2780101021 @default.
- W2010291223 hasConceptScore W2010291223C2780275930 @default.
- W2010291223 hasConceptScore W2010291223C526584372 @default.
- W2010291223 hasConceptScore W2010291223C530470458 @default.
- W2010291223 hasConceptScore W2010291223C71924100 @default.
- W2010291223 hasConceptScore W2010291223C90924648 @default.
- W2010291223 hasIssue "12" @default.
- W2010291223 hasLocation W20102912231 @default.
- W2010291223 hasLocation W20102912232 @default.
- W2010291223 hasOpenAccess W2010291223 @default.
- W2010291223 hasPrimaryLocation W20102912231 @default.
- W2010291223 hasRelatedWork W1583066846 @default.
- W2010291223 hasRelatedWork W2010291223 @default.
- W2010291223 hasRelatedWork W2074798205 @default.
- W2010291223 hasRelatedWork W2137349481 @default.
- W2010291223 hasRelatedWork W2596355280 @default.
- W2010291223 hasRelatedWork W2748952813 @default.
- W2010291223 hasRelatedWork W2802175037 @default.
- W2010291223 hasRelatedWork W2910969278 @default.
- W2010291223 hasRelatedWork W2946819540 @default.
- W2010291223 hasRelatedWork W4213392687 @default.
- W2010291223 hasVolume "29" @default.
- W2010291223 isParatext "false" @default.
- W2010291223 isRetracted "false" @default.
- W2010291223 magId "2010291223" @default.
- W2010291223 workType "article" @default.