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• W2010295908 abstract "Background: In comparison with many nuclear proteins, the movement of chromatin in nuclei appears to be generally constrained. These restrictions on motion are proposed to reflect the attachment of chromatin to immobile nuclear substructures.Results: To gain insight into the regulation of chromosome dynamics by nuclear architecture, we have followed the movements of different sites in the human genome in living cells. Here, we show that loci at nucleoli or the nuclear periphery are significantly less mobile than other, more nucleoplasmic loci. Disruption of nucleoli increases the mobility of nucleolar-associated loci.Conclusions: This is the first report of distinct nuclear substructures constraining the movements of chromatin. These constraints reflect the physical attachment of chromatin to nuclear compartments or steric impairment caused by local ultrastructure. Our data suggest a role for the nucleolus and nuclear periphery in maintaining the three-dimensional organization of chromatin in the human nucleus." @default.
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• W2010295908 date "2002-03-01" @default.
• W2010295908 modified "2023-10-17" @default.
• W2010295908 title "Chromatin Motion Is Constrained by Association with Nuclear Compartments in Human Cells" @default.
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• W2010295908 doi "https://doi.org/10.1016/s0960-9822(02)00695-4" @default.
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