FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010296057> ?p ?o ?g. }

• W2010296057 endingPage "53" @default.
• W2010296057 startingPage "46" @default.
• W2010296057 abstract "Background. Sirolimus plays a critical role in facilitating steroid-free immunosuppression, in conjunction with low dose tacrolimus, in current islet transplantation. Although several studies have investigated the effects of sirolimus on islet cells, conflicting results have been reported. In this study, we assessed the effects of sirolimus supplementation in culture media on human islet preparations, focusing on the anti-proinflammatory aspects. Methods. Human islet preparations were divided into four groups: pure (purity >90%) sirolimus (30 ng/mL); pure control (0 ng/mL); impure (purity 40%–60%) sirolimus; and impure control. All groups were cultured for 3 days and assessed regarding glucose stimulated insulin release, fractional β-cell viability, β-cell, and macrophage content. Cytokine and chemokine production from islet preparations and sorted pancreatic ductal cells were also examined. Results. Stimulated insulin release in the impure sirolimus group was significantly increased (P=0.024), as previously reported. Although fractional β-cell viability showed no significant differences, β-cell survival during culture significantly increased in impure sirolimus group when compared with the impure control group (P=0.015). Tumor necrosis factor-α, interleukin-1β, monocyte chemotactic protein-1, and macrophage inflammatory protein-1β production from the impure sirolimus group significantly decreased (P<0.05). Furthermore, tumor necrosis factor-α and macrophage inflammatory protein-1β production from sorted ductal cells significantly decreased in the sirolimus group (P<0.05). The number of macrophages contained in islet preparations significantly decreased in the impure sirolimus group when compared with the impure control group (P<0.05). Conclusions. Sirolimus improved not only stimulated insulin release, but also β-cell survival during culture. The antiinflammatory effects of sirolimus also appear beneficial to islet cells in culture and may be a useful strategy in improving islet transplantation outcomes." @default.
• W2010296057 created "2016-06-24" @default.
• W2010296057 creator A5009500557 @default.
• W2010296057 creator A5021522402 @default.
• W2010296057 creator A5027764488 @default.
• W2010296057 creator A5044474967 @default.
• W2010296057 creator A5045421835 @default.
• W2010296057 creator A5061892200 @default.
• W2010296057 creator A5075027552 @default.
• W2010296057 creator A5078381271 @default.
• W2010296057 creator A5078992177 @default.
• W2010296057 creator A5084833160 @default.
• W2010296057 date "2008-07-15" @default.
• W2010296057 modified "2023-10-16" @default.
• W2010296057 title "Anti-Proinflammatory Effects of Sirolimus on Human Islet Preparations" @default.
• W2010296057 cites W1647027131 @default.
• W2010296057 cites W1973332713 @default.
• W2010296057 cites W1976874472 @default.
• W2010296057 cites W1976990715 @default.
• W2010296057 cites W1981163610 @default.
• W2010296057 cites W2003413342 @default.
• W2010296057 cites W2004393870 @default.
• W2010296057 cites W2021668967 @default.
• W2010296057 cites W2030698866 @default.
• W2010296057 cites W2034183783 @default.
• W2010296057 cites W2035171266 @default.
• W2010296057 cites W2041496770 @default.
• W2010296057 cites W2048438191 @default.
• W2010296057 cites W2053090718 @default.
• W2010296057 cites W2055201358 @default.
• W2010296057 cites W2056176542 @default.
• W2010296057 cites W2057211711 @default.
• W2010296057 cites W2073282913 @default.
• W2010296057 cites W2080340090 @default.
• W2010296057 cites W2086293677 @default.
• W2010296057 cites W2092847255 @default.
• W2010296057 cites W2095211207 @default.
• W2010296057 cites W2095241070 @default.
• W2010296057 cites W2099113735 @default.
• W2010296057 cites W2103302057 @default.
• W2010296057 cites W2108040825 @default.
• W2010296057 cites W2111298415 @default.
• W2010296057 cites W2113290184 @default.
• W2010296057 cites W2121218238 @default.
• W2010296057 cites W2133186034 @default.
• W2010296057 cites W2136127635 @default.
• W2010296057 cites W2144282451 @default.
• W2010296057 cites W2145047873 @default.
• W2010296057 cites W2146510025 @default.
• W2010296057 cites W2150724212 @default.
• W2010296057 cites W2151777294 @default.
• W2010296057 cites W2152559266 @default.
• W2010296057 cites W2154914870 @default.
• W2010296057 cites W2158844203 @default.
• W2010296057 cites W2161993072 @default.
• W2010296057 cites W2171678230 @default.
• W2010296057 cites W2324941813 @default.
• W2010296057 cites W2328786770 @default.
• W2010296057 doi "https://doi.org/10.1097/tp.0b013e31817c79c0" @default.
• W2010296057 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2650480" @default.
• W2010296057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18622277" @default.
• W2010296057 hasPublicationYear "2008" @default.
• W2010296057 type Work @default.
• W2010296057 sameAs 2010296057 @default.
• W2010296057 citedByCount "21" @default.
• W2010296057 countsByYear W20102960572012 @default.
• W2010296057 countsByYear W20102960572013 @default.
• W2010296057 countsByYear W20102960572014 @default.
• W2010296057 countsByYear W20102960572015 @default.
• W2010296057 countsByYear W20102960572016 @default.
• W2010296057 countsByYear W20102960572017 @default.
• W2010296057 countsByYear W20102960572019 @default.
• W2010296057 countsByYear W20102960572020 @default.
• W2010296057 countsByYear W20102960572021 @default.
• W2010296057 crossrefType "journal-article" @default.
• W2010296057 hasAuthorship W2010296057A5009500557 @default.
• W2010296057 hasAuthorship W2010296057A5021522402 @default.
• W2010296057 hasAuthorship W2010296057A5027764488 @default.
• W2010296057 hasAuthorship W2010296057A5044474967 @default.
• W2010296057 hasAuthorship W2010296057A5045421835 @default.
• W2010296057 hasAuthorship W2010296057A5061892200 @default.
• W2010296057 hasAuthorship W2010296057A5075027552 @default.
• W2010296057 hasAuthorship W2010296057A5078381271 @default.
• W2010296057 hasAuthorship W2010296057A5078992177 @default.
• W2010296057 hasAuthorship W2010296057A5084833160 @default.
• W2010296057 hasBestOaLocation W20102960571 @default.
• W2010296057 hasConcept C126322002 @default.
• W2010296057 hasConcept C128057223 @default.
• W2010296057 hasConcept C13373296 @default.
• W2010296057 hasConcept C134018914 @default.
• W2010296057 hasConcept C164027704 @default.
• W2010296057 hasConcept C165220095 @default.
• W2010296057 hasConcept C16685009 @default.
• W2010296057 hasConcept C17991360 @default.
• W2010296057 hasConcept C185592680 @default.
• W2010296057 hasConcept C2776914184 @default.
• W2010296057 hasConcept C2777411314 @default.
• W2010296057 hasConcept C2777921159 @default.

• next