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• W2010298857 abstract "In the present study, the effects of intra-central amygdala (CeA) injections of dopamine (DA) D2-like receptor agonist and antagonist on the acquisition and expression of morphine-induced place preference in male Wistar rats have been investigated. Subcutaneous administration of different doses of morphine sulphate (0.5–10 mg/kg) produced a dose-dependent conditioned place preference (CPP). Using a 3-day schedule of conditioning, it was found that the DA D2/D3 receptor agonist, quinpirole (0.3–3 μg/rat), or the DA D2 receptor antagonist, sulpiride (0.04–5 μg/rat), did not produce a significant place preference or place aversion. Intra-CeA administration of quinpirole (0.3 and 1 μg/rat) with an ineffective dose of morphine (0.5 mg/kg) elicited a significant CPP. On the other hand, quinpirole (0.3 μg/rat) injection into the CeA induced CPP in combination with the lower doses of morphine (0.5 and 2.5 mg/kg), but decreased the response of higher dose (7.5 mg/kg) of morphine. This response of quinpirole was attenuated by sulpiride (0.2 μg/rat). Sulpiride by itself (0.04–5 μg/rat) reduced the acquisition of morphine (7.5 mg/kg)-induced place preference. The administration of the higher dose of sulpiride (1 and 5 μg/rat) or the higher dose of quinpirole (3 μg/rat) during acquisition decreased the locomotor activity of the animals on the testing days. The injection of the low dose of quinpirole (0.3 μg/rat) on the test day reduced the expression of morphine-induced CPP, but the high dose of quinpirole (3 μg/rat) potentiated this expression. The administration of sulpiride (5 μg/rat) attenuated the quinpirole response. The injection of sulpiride (1 and 5 μg/rat) abolished the expression of morphine-induced CPP. It is concluded that the CeA DA D2-like receptors may play an active role in morphine reward." @default.
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• W2010298857 date "2002-12-01" @default.
• W2010298857 modified "2023-10-17" @default.
• W2010298857 title "Involvement of dopamine D2 receptors of the central amygdala on the acquisition and expression of morphine-induced place preference in rat" @default.
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• W2010298857 doi "https://doi.org/10.1016/s0091-3057(02)00989-9" @default.
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