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- W2010302007 abstract "Epidemiological studies have associated infection during pregnancy with increased risk of neurodevelopmental disorders in children, which is modeled in rodents by stimulating the immune system of pregnant dams with microorganisms or their mimics, such as poly(I:C) or LPS. In two prenatal mouse models, we show that in utero exposure of the fetus to cytokines/inflammatory mediators elicited by maternal immune stimulation with poly(I:C) yields offspring that exhibit a proinflammatory phenotype due to alterations in developmental programming of their immune system. Changes in the innate and adaptive immune elements of these pro-inflammatory offspring result in more robust responses following exposure to immune stimuli than those observed in control offspring from PBS-injected pregnant dams. In the first model, offspring from poly(I:C)-injected immunologically naïve dams showed heightened cellular and cytokine responses 4 h after injection of zymosan, a TLR2 agonist. In the second model, using dams with immunological memory, poly(I:C) injection during pregnancy produced offspring that showed preferential differentiation toward Th17 cell development, earlier onset of clinical symptoms of EAE, and more severe neurological deficits following immunization with MOG35-55. Such fetal programming in offspring from poly(I:C)-injected dams not only persists into neonatal and adult life, but also can have profound consequences on health and disease." @default.
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- W2010302007 date "2013-10-01" @default.
- W2010302007 modified "2023-10-09" @default.
- W2010302007 title "Maternal immune stimulation during pregnancy shapes the immunological phenotype of offspring" @default.
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- W2010302007 cites W1622357346 @default.
- W2010302007 cites W1637128412 @default.
- W2010302007 cites W1769758822 @default.
- W2010302007 cites W1773383907 @default.
- W2010302007 cites W1959664751 @default.
- W2010302007 cites W1966934571 @default.
- W2010302007 cites W1969046656 @default.
- W2010302007 cites W1971233916 @default.
- W2010302007 cites W1972223787 @default.
- W2010302007 cites W1973779570 @default.
- W2010302007 cites W1976250464 @default.
- W2010302007 cites W1978125777 @default.
- W2010302007 cites W1987331740 @default.
- W2010302007 cites W1989871271 @default.
- W2010302007 cites W1994473536 @default.
- W2010302007 cites W1994600097 @default.
- W2010302007 cites W1998000193 @default.
- W2010302007 cites W1998944144 @default.
- W2010302007 cites W1999771966 @default.
- W2010302007 cites W2005897950 @default.
- W2010302007 cites W2007305673 @default.
- W2010302007 cites W2009396016 @default.
- W2010302007 cites W2022230955 @default.
- W2010302007 cites W2028935955 @default.
- W2010302007 cites W2031337229 @default.
- W2010302007 cites W2032096424 @default.
- W2010302007 cites W2034778776 @default.
- W2010302007 cites W2035713221 @default.
- W2010302007 cites W2040789766 @default.
- W2010302007 cites W2041812587 @default.
- W2010302007 cites W2043709066 @default.
- W2010302007 cites W2043943546 @default.
- W2010302007 cites W2045720698 @default.
- W2010302007 cites W2050179923 @default.
- W2010302007 cites W2056912730 @default.
- W2010302007 cites W2061931936 @default.
- W2010302007 cites W2062278012 @default.
- W2010302007 cites W2063299997 @default.
- W2010302007 cites W2071205488 @default.
- W2010302007 cites W2073177635 @default.
- W2010302007 cites W2075746515 @default.
- W2010302007 cites W2078827499 @default.
- W2010302007 cites W2080459142 @default.
- W2010302007 cites W2080499615 @default.
- W2010302007 cites W2087685632 @default.
- W2010302007 cites W2091975706 @default.
- W2010302007 cites W2097404490 @default.
- W2010302007 cites W2097723382 @default.
- W2010302007 cites W2098053278 @default.
- W2010302007 cites W2100463268 @default.
- W2010302007 cites W2100543150 @default.
- W2010302007 cites W2101683974 @default.
- W2010302007 cites W2105035544 @default.
- W2010302007 cites W2112851246 @default.
- W2010302007 cites W2112866067 @default.
- W2010302007 cites W2113755136 @default.
- W2010302007 cites W2116134868 @default.
- W2010302007 cites W2121095822 @default.
- W2010302007 cites W2126795224 @default.
- W2010302007 cites W2131187621 @default.
- W2010302007 cites W2132438753 @default.
- W2010302007 cites W2136229089 @default.
- W2010302007 cites W2138694950 @default.
- W2010302007 cites W2141645427 @default.
- W2010302007 cites W2142972284 @default.
- W2010302007 cites W2143217444 @default.
- W2010302007 cites W2154965665 @default.
- W2010302007 cites W2156362038 @default.
- W2010302007 cites W2157489226 @default.
- W2010302007 cites W2159252214 @default.
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- W2010302007 cites W2169002310 @default.
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- W2010302007 doi "https://doi.org/10.1016/j.bbi.2013.04.012" @default.
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