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• W2010309574 startingPage "1511" @default.
• W2010309574 abstract "In the absence of their own translational machinery, all viruses must gain access to host cell ribosomes to synthesize viral proteins and replicate. Ribosome recruitment and scanning of capped host mRNAs is facilitated by the multisubunit eIF (eukaryotic initiation factor) 4F, which consists of a cap-binding protein, eIF4E and an RNA helicase, eIF4A, assembled on a large scaffolding protein, eIF4G. Although inactivated by many viruses to inhibit host translation, a growing number of DNA viruses are being found to employ diverse strategies to stimulate eIF4F activity in infected cells and maximize viral protein synthesis. These strategies include stimulation of cellular mTOR (mammalian target of rapamycin) signalling to inactivate 4E-BPs (eIF4E-binding proteins), a family of translational repressors that limit eIF4E availability and eIF4F complex formation, together with modulating the activity of the eIF4E kinase Mnk (mitogen-activated protein kinase signal-integrating kinase) in a variety of manners to regulate both host and viral mRNA translation. In some cases, specific viral proteins that mediate these signalling events have been identified, whereas others have been shown to interact with host translation initiation factors or complexes and modify their activity and/or subcellular localization. The present review outlines current understanding of the role of eIF4F in the life cycle of various DNA viruses and discusses its potential as a therapeutic target to suppress viral infection." @default.
• W2010309574 created "2016-06-24" @default.
• W2010309574 creator A5048434095 @default.
• W2010309574 date "2010-11-24" @default.
• W2010309574 modified "2023-10-18" @default.
• W2010309574 title "Manipulation of the host translation initiation complex eIF4F by DNA viruses" @default.
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• W2010309574 cites W1981186210 @default.
• W2010309574 cites W1983841815 @default.
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• W2010309574 doi "https://doi.org/10.1042/bst0381511" @default.
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