FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010318629> ?p ?o ?g. }

• W2010318629 endingPage "581" @default.
• W2010318629 startingPage "570" @default.
• W2010318629 abstract "Chk tyrosine kinase phosphorylates Src-family tyrosine kinases and suppresses their kinase activity. We recently showed that Chk localizes to the nucleus as well as the cytoplasm and inhibits cell proliferation. To investigate the role of nuclear Chk in proliferation, various Chk mutants were constructed and expressed. Nuclear localization of Chk-induced dynamic multi-lobulation of the nucleus and prolonged S phase of the cell cycle. The N-terminal domain of Chk and a portion of its kinase domain but not the kinase activity were responsible for induction of the multi-lobulation. Cell sorting analysis revealed that nuclear multi-lobulated cells were enriched in late S phase. Multi-lobulated nuclei were surrounded with lamin B1 that was particularly concentrated in concave regions of the nuclei. Furthermore, treatment with nocodazole or taxol disrupted multi-lobulation of the nucleus. These results suggest that nuclear multi-lobulation in late S phase, which is dependent on polymerization and depolymerization of microtubules, may be involved in nuclear Chk-induced inhibition of proliferation." @default.
• W2010318629 created "2016-06-24" @default.
• W2010318629 creator A5019397425 @default.
• W2010318629 creator A5058098685 @default.
• W2010318629 date "2005-04-01" @default.
• W2010318629 modified "2023-10-02" @default.
• W2010318629 title "Multi-lobulation of the nucleus in prolonged S phase by nuclear expression of Chk tyrosine kinase" @default.
• W2010318629 cites W1541096553 @default.
• W2010318629 cites W1585985640 @default.
• W2010318629 cites W1622325070 @default.
• W2010318629 cites W1955474383 @default.
• W2010318629 cites W1964946285 @default.
• W2010318629 cites W1971934332 @default.
• W2010318629 cites W1975778708 @default.
• W2010318629 cites W1986402178 @default.
• W2010318629 cites W2007058418 @default.
• W2010318629 cites W2012545068 @default.
• W2010318629 cites W2014089858 @default.
• W2010318629 cites W2015990519 @default.
• W2010318629 cites W2019182965 @default.
• W2010318629 cites W2020520526 @default.
• W2010318629 cites W2028603863 @default.
• W2010318629 cites W2038214146 @default.
• W2010318629 cites W2042487912 @default.
• W2010318629 cites W2055276390 @default.
• W2010318629 cites W2057522260 @default.
• W2010318629 cites W2062256468 @default.
• W2010318629 cites W2064812124 @default.
• W2010318629 cites W2066353180 @default.
• W2010318629 cites W2069910674 @default.
• W2010318629 cites W2072720547 @default.
• W2010318629 cites W2075265463 @default.
• W2010318629 cites W2080125477 @default.
• W2010318629 cites W2088365475 @default.
• W2010318629 cites W2090831635 @default.
• W2010318629 cites W2102101621 @default.
• W2010318629 cites W2103330925 @default.
• W2010318629 cites W2115501699 @default.
• W2010318629 cites W2121405186 @default.
• W2010318629 cites W2142939796 @default.
• W2010318629 cites W2158799849 @default.
• W2010318629 cites W2161733130 @default.
• W2010318629 cites W2161799830 @default.
• W2010318629 cites W2168836733 @default.
• W2010318629 cites W2295049711 @default.
• W2010318629 cites W2339422997 @default.
• W2010318629 doi "https://doi.org/10.1016/j.yexcr.2004.11.027" @default.
• W2010318629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15748901" @default.
• W2010318629 hasPublicationYear "2005" @default.
• W2010318629 type Work @default.
• W2010318629 sameAs 2010318629 @default.
• W2010318629 citedByCount "50" @default.
• W2010318629 countsByYear W20103186292012 @default.
• W2010318629 countsByYear W20103186292013 @default.
• W2010318629 countsByYear W20103186292014 @default.
• W2010318629 countsByYear W20103186292015 @default.
• W2010318629 countsByYear W20103186292016 @default.
• W2010318629 countsByYear W20103186292018 @default.
• W2010318629 countsByYear W20103186292019 @default.
• W2010318629 countsByYear W20103186292021 @default.
• W2010318629 countsByYear W20103186292022 @default.
• W2010318629 countsByYear W20103186292023 @default.
• W2010318629 crossrefType "journal-article" @default.
• W2010318629 hasAuthorship W2010318629A5019397425 @default.
• W2010318629 hasAuthorship W2010318629A5058098685 @default.
• W2010318629 hasConcept C142669718 @default.
• W2010318629 hasConcept C1491633281 @default.
• W2010318629 hasConcept C153911025 @default.
• W2010318629 hasConcept C184235292 @default.
• W2010318629 hasConcept C190062978 @default.
• W2010318629 hasConcept C20418707 @default.
• W2010318629 hasConcept C2776165026 @default.
• W2010318629 hasConcept C2779363559 @default.
• W2010318629 hasConcept C2780114586 @default.
• W2010318629 hasConcept C2780723820 @default.
• W2010318629 hasConcept C42362537 @default.
• W2010318629 hasConcept C55493867 @default.
• W2010318629 hasConcept C62112901 @default.
• W2010318629 hasConcept C62478195 @default.
• W2010318629 hasConcept C86803240 @default.
• W2010318629 hasConcept C95444343 @default.
• W2010318629 hasConceptScore W2010318629C142669718 @default.
• W2010318629 hasConceptScore W2010318629C1491633281 @default.
• W2010318629 hasConceptScore W2010318629C153911025 @default.
• W2010318629 hasConceptScore W2010318629C184235292 @default.
• W2010318629 hasConceptScore W2010318629C190062978 @default.
• W2010318629 hasConceptScore W2010318629C20418707 @default.
• W2010318629 hasConceptScore W2010318629C2776165026 @default.
• W2010318629 hasConceptScore W2010318629C2779363559 @default.
• W2010318629 hasConceptScore W2010318629C2780114586 @default.
• W2010318629 hasConceptScore W2010318629C2780723820 @default.
• W2010318629 hasConceptScore W2010318629C42362537 @default.
• W2010318629 hasConceptScore W2010318629C55493867 @default.
• W2010318629 hasConceptScore W2010318629C62112901 @default.
• W2010318629 hasConceptScore W2010318629C62478195 @default.
• W2010318629 hasConceptScore W2010318629C86803240 @default.
• W2010318629 hasConceptScore W2010318629C95444343 @default.
• W2010318629 hasFunder F4320320912 @default.

• next