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- W2010325249 abstract "TANI, K., FUJII, H., MIWA, S., IMANAKA, F., KURAMOTO, A, and ISHIKAWA, H. Phosphofructokinase Deficiency Associated with Congenital Nonspherocytic Hemolytic Anemia and Mild Myopathy: Biochemical and Morphological Studies on the Muscle. Tohoku J. exp. Med., 1983, 141 (3), 287-293 - Enzymatic and electron microscopical studies were performed on the muscle of a proband with phosphofructokinase deficiency. Enzymatic studies showed that muscle phosphofructokinase activity of the proband was decreased to about a half of normal. This enzyme was quite thermolabile and had low affinity for fructose 6-phosphate. Electron microscopical studies showed the accumulation of glycogen granules beneath the sarcolemma and between the myofibrils in spite of a lack of accumulation of the intermediates before the step of phosphofructokinase. The proband's clinical symptoms, i.e., hemolytic anemia and myopathy, were considered to be due to the unstable, mutant, muscle-type phosphofructokinase in the red blood cells and muscle." @default.
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- W2010325249 date "1983-01-01" @default.
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- W2010325249 title "Phosphofructokinase deficiency associated with congenital nonspherocytic hemolytic anemia and mild myopathy: Biochemical and morphological studies on the muscle." @default.
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- W2010325249 doi "https://doi.org/10.1620/tjem.141.287" @default.
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