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- W2010327147 abstract "The ability of opioids to influence rectal temperature after injection into the periaqueductal grey region (PAG) of rat brain was investigated. Both morphine and β-endorphin caused a dose-dependent increase in rectal temperature of up to 2°C. By using selective ligands of the subclasses of opiate receptor such as [d-Ala2,d-Leu5]enkephalin for δ-receptors and ethylketocyclazocine, dynorphin(1–17) and dynorphin(1–8) for κ-receptors, it was possible to show that neither the δ- nor the κ-opiate receptor was involved in the hyperthermic response. However, [d-Ala2,MePhe4,Gly-ol5]enkephalin (DAGO), a μ-receptor ligand, did produce a dose-dependent hyperthermia. The ability of naltrexone, an opiate receptor antagonist, to reverse the hyperthermia induced by β-endorphin and DAGO suggests that the opioid-stimulated increase in body temperature via the PAG is mediated through the μ-opiate receptor. Since the application of opioids to the PAG produces a hyperthermic response, it is possible that this brain site may have a role in the peptidergic control of body temperature." @default.
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- W2010327147 title "Body temperature effects of opioids administered into the periaqueductal grey area of rat brain" @default.
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- W2010327147 doi "https://doi.org/10.1016/0167-0115(83)90019-8" @default.
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