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• W2010334590 startingPage "366" @default.
• W2010334590 abstract "Hypertrophic cardiomyopathy (HCM), characterized by cardiac hypertrophy and contractile dysfunction, is a major cause of heart failure. HCM can result from mutations in the gene encoding cardiac α-tropomyosin (TM). To understand how the HCM-causing Asp175Asn and Glu180Gly mutations in α-tropomyosin affect on actin–myosin interaction during the ATPase cycle, we labeled the SH1 helix of myosin subfragment-1 and the actin subdomain-1 with the fluorescent probe N-iodoacetyl-N′-(5-sulfo-1-naphtylo)ethylenediamine. These proteins were incorporated into ghost muscle fibers and their conformational states were monitored during the ATPase cycle by measuring polarized fluorescence. For the first time, the effect of these α-tropomyosins on the mobility and rotation of subdomain-1 of actin and the SH1 helix of myosin subfragment-1 during the ATP hydrolysis cycle have been demonstrated directly by polarized fluorimetry. Wild-type α-tropomyosin increases the amplitude of the SH1 helix and subdomain-1 movements during the ATPase cycle, indicating the enhancement of the efficiency of the work of cross-bridges. Both mutant TMs increase the proportion of the strong-binding sub-states, with the effect of the Glu180Gly mutation being greater than that of Asp175Asn. It is suggested that the alteration in the concerted conformational changes of actomyosin is likely to provide the structural basis for the altered cardiac muscle contraction." @default.
• W2010334590 created "2016-06-24" @default.
• W2010334590 creator A5022541498 @default.
• W2010334590 creator A5046447164 @default.
• W2010334590 creator A5078601953 @default.
• W2010334590 creator A5090129579 @default.
• W2010334590 date "2012-02-01" @default.
• W2010334590 modified "2023-09-30" @default.
• W2010334590 title "The effect of the Asp175Asn and Glu180Gly TPM1 mutations on actin–myosin interaction during the ATPase cycle" @default.
• W2010334590 cites W104354955 @default.
• W2010334590 cites W1481760785 @default.
• W2010334590 cites W1521008149 @default.
• W2010334590 cites W1531580640 @default.
• W2010334590 cites W1538692246 @default.
• W2010334590 cites W1578606251 @default.
• W2010334590 cites W1593046472 @default.
• W2010334590 cites W1753453251 @default.
• W2010334590 cites W1966597610 @default.
• W2010334590 cites W1971393829 @default.
• W2010334590 cites W1973555633 @default.
• W2010334590 cites W1974381583 @default.
• W2010334590 cites W1979795602 @default.
• W2010334590 cites W1982116077 @default.
• W2010334590 cites W1982411526 @default.
• W2010334590 cites W1983332812 @default.
• W2010334590 cites W1984329061 @default.
• W2010334590 cites W1984943062 @default.
• W2010334590 cites W1988039849 @default.
• W2010334590 cites W1989461632 @default.
• W2010334590 cites W1992924616 @default.
• W2010334590 cites W2001777476 @default.
• W2010334590 cites W2002966321 @default.
• W2010334590 cites W2003563607 @default.
• W2010334590 cites W2004561249 @default.
• W2010334590 cites W2007110441 @default.
• W2010334590 cites W2010337484 @default.
• W2010334590 cites W2013513231 @default.
• W2010334590 cites W2015258673 @default.
• W2010334590 cites W2015569643 @default.
• W2010334590 cites W2017556218 @default.
• W2010334590 cites W2019434932 @default.
• W2010334590 cites W2019642207 @default.
• W2010334590 cites W2020521591 @default.
• W2010334590 cites W2021925088 @default.
• W2010334590 cites W2024362819 @default.
• W2010334590 cites W2029684514 @default.
• W2010334590 cites W2035096578 @default.
• W2010334590 cites W2035703000 @default.
• W2010334590 cites W2038936188 @default.
• W2010334590 cites W2040635619 @default.
• W2010334590 cites W2044629144 @default.
• W2010334590 cites W2045913132 @default.
• W2010334590 cites W2046296155 @default.
• W2010334590 cites W2050836758 @default.
• W2010334590 cites W2052580795 @default.
• W2010334590 cites W2058369632 @default.
• W2010334590 cites W2059892055 @default.
• W2010334590 cites W2060907201 @default.
• W2010334590 cites W2062207513 @default.
• W2010334590 cites W2064935758 @default.
• W2010334590 cites W2064936698 @default.
• W2010334590 cites W2066020252 @default.
• W2010334590 cites W2067121447 @default.
• W2010334590 cites W207706498 @default.
• W2010334590 cites W2077483294 @default.
• W2010334590 cites W2081295078 @default.
• W2010334590 cites W2083998431 @default.
• W2010334590 cites W2086653054 @default.
• W2010334590 cites W2088351106 @default.
• W2010334590 cites W2090855399 @default.
• W2010334590 cites W2092936803 @default.
• W2010334590 cites W2093711590 @default.
• W2010334590 cites W2094248488 @default.
• W2010334590 cites W2094656982 @default.
• W2010334590 cites W2095487467 @default.
• W2010334590 cites W2104396876 @default.
• W2010334590 cites W2109101320 @default.
• W2010334590 cites W2117845893 @default.
• W2010334590 cites W2121564730 @default.
• W2010334590 cites W2146691714 @default.
• W2010334590 cites W2147062922 @default.
• W2010334590 cites W2166966672 @default.
• W2010334590 cites W2169691331 @default.
• W2010334590 cites W2170483942 @default.
• W2010334590 cites W2312518076 @default.
• W2010334590 cites W30243768 @default.
• W2010334590 cites W41046980 @default.
• W2010334590 cites W4230385085 @default.
• W2010334590 cites W4240038798 @default.
• W2010334590 cites W4246986196 @default.
• W2010334590 doi "https://doi.org/10.1016/j.bbapap.2011.11.004" @default.
• W2010334590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22155441" @default.
• W2010334590 hasPublicationYear "2012" @default.
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