FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010335307> ?p ?o ?g. }

• W2010335307 endingPage "2061" @default.
• W2010335307 startingPage "2052" @default.
• W2010335307 abstract "Signal transduction in outer segments of vertebrate photoreceptors is mediated by a series of reactions among multiple polypeptides that form protein-protein complexes within or on the surface of the disk and plasma membranes. The individual components in the activation reactions include the photon receptor rhodopsin and the products of its absorption of light, the three subunits of the G protein, transducin, the four subunits of the cGMP phosphodiesterase, PDE6 and the four subunits of the cGMP-gated cation channel. Recovery involves membrane complexes with additional polypeptides including the Na(+)/Ca(2+), K(+) exchanger, NCKX2, rhodopsin kinases RK1 and RK7, arrestin, guanylate cyclases, guanylate cyclase activating proteins, GCAP1 and GCAP2, and the GTPase accelerating complex of RGS9-1, G(beta5L), and membrane anchor R9AP. Modes of membrane binding by these polypeptides include transmembrane helices, fatty acyl or isoprenyl modifications, polar interactions with lipid head groups, non-polar interactions of hydrophobic side chains with lipid hydrocarbon phase, and both polar and non-polar protein-protein interactions. In the course of signal transduction, complexes among these polypeptides form and dissociate, and undergo structural rearrangements that are coupled to their interactions with and catalysis of reactions by small molecules and ions, including guanine nucleotides, ATP, Ca(2+), Mg(2+), and lipids. The substantial progress that has been made in understanding the composition and function of these complexes is reviewed, along with the more preliminary state of our understanding of the structures of these complexes and the challenges and opportunities that present themselves for deepening our understanding of these complexes, and how they work together to convert a light signal into an electrical signal." @default.
• W2010335307 created "2016-06-24" @default.
• W2010335307 creator A5046811013 @default.
• W2010335307 date "2008-09-01" @default.
• W2010335307 modified "2023-10-16" @default.
• W2010335307 title "Signal transducing membrane complexes of photoreceptor outer segments" @default.
• W2010335307 cites W1494856533 @default.
• W2010335307 cites W1503336891 @default.
• W2010335307 cites W1511567109 @default.
• W2010335307 cites W1523961007 @default.
• W2010335307 cites W1527909374 @default.
• W2010335307 cites W1533371356 @default.
• W2010335307 cites W1536091221 @default.
• W2010335307 cites W1546721600 @default.
• W2010335307 cites W1546944826 @default.
• W2010335307 cites W1550806901 @default.
• W2010335307 cites W1566497779 @default.
• W2010335307 cites W1576457008 @default.
• W2010335307 cites W1580328099 @default.
• W2010335307 cites W1585153832 @default.
• W2010335307 cites W1586063439 @default.
• W2010335307 cites W1601396769 @default.
• W2010335307 cites W1607303892 @default.
• W2010335307 cites W1624926237 @default.
• W2010335307 cites W1671361404 @default.
• W2010335307 cites W1726226860 @default.
• W2010335307 cites W1760752158 @default.
• W2010335307 cites W1794037884 @default.
• W2010335307 cites W181525583 @default.
• W2010335307 cites W1885923677 @default.
• W2010335307 cites W1966321788 @default.
• W2010335307 cites W1966619635 @default.
• W2010335307 cites W1968093517 @default.
• W2010335307 cites W196830743 @default.
• W2010335307 cites W1969595890 @default.
• W2010335307 cites W1970384111 @default.
• W2010335307 cites W1970806709 @default.
• W2010335307 cites W1976392879 @default.
• W2010335307 cites W1977085484 @default.
• W2010335307 cites W1977700439 @default.
• W2010335307 cites W1978798664 @default.
• W2010335307 cites W1978846511 @default.
• W2010335307 cites W1988127541 @default.
• W2010335307 cites W1988640416 @default.
• W2010335307 cites W1988803741 @default.
• W2010335307 cites W1988985422 @default.
• W2010335307 cites W1989433038 @default.
• W2010335307 cites W1990457307 @default.
• W2010335307 cites W1991544676 @default.
• W2010335307 cites W1991923195 @default.
• W2010335307 cites W1991994451 @default.
• W2010335307 cites W1992004763 @default.
• W2010335307 cites W1993606042 @default.
• W2010335307 cites W1993697025 @default.
• W2010335307 cites W1994953274 @default.
• W2010335307 cites W1997328693 @default.
• W2010335307 cites W1998732178 @default.
• W2010335307 cites W1999493392 @default.
• W2010335307 cites W2000444382 @default.
• W2010335307 cites W2001525211 @default.
• W2010335307 cites W2003600819 @default.
• W2010335307 cites W2004125744 @default.
• W2010335307 cites W2004581292 @default.
• W2010335307 cites W2005350874 @default.
• W2010335307 cites W2006307429 @default.
• W2010335307 cites W2007222638 @default.
• W2010335307 cites W2008981610 @default.
• W2010335307 cites W2010201306 @default.
• W2010335307 cites W2010265574 @default.
• W2010335307 cites W2011301782 @default.
• W2010335307 cites W2011546287 @default.
• W2010335307 cites W2011645175 @default.
• W2010335307 cites W2014269943 @default.
• W2010335307 cites W2014899116 @default.
• W2010335307 cites W2018518508 @default.
• W2010335307 cites W2019172090 @default.
• W2010335307 cites W2019527106 @default.
• W2010335307 cites W2020679755 @default.
• W2010335307 cites W2021008077 @default.
• W2010335307 cites W2021582859 @default.
• W2010335307 cites W2022425508 @default.
• W2010335307 cites W2023343036 @default.
• W2010335307 cites W2023618509 @default.
• W2010335307 cites W2024847911 @default.
• W2010335307 cites W2024952995 @default.
• W2010335307 cites W2026771742 @default.
• W2010335307 cites W2028426734 @default.
• W2010335307 cites W2028949252 @default.
• W2010335307 cites W2029347326 @default.
• W2010335307 cites W2029896705 @default.
• W2010335307 cites W2030185192 @default.
• W2010335307 cites W2031463348 @default.
• W2010335307 cites W2031664450 @default.
• W2010335307 cites W2031682891 @default.
• W2010335307 cites W2032999356 @default.
• W2010335307 cites W2036584166 @default.
• W2010335307 cites W2037594168 @default.
• W2010335307 cites W2037767676 @default.

• next