Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010336457> ?p ?o ?g. }
- W2010336457 abstract "Despite major advances in genetic and structural studies of the HLA-B27 antigen, the underlying mechanism responsible for the remarkable association between this antigen and spondylarthropathies remains unknown. At a molecular level, the use of B27M1 and B27M2 monoclonal antibodies has permitted the identification of distinct allospecific epitopes on the B27 molecule. One of these epitopes, B27M2, is polymorphic and has allowed us to define B27 variants: B27M2[+], B27M2[-], and B27M2[int]. The heterogeneity of the B27 antigen correlates well with biochemical and cytotoxic evidence of genetic heterogeneity. These variants exhibit ethnic variation and also appear to correlate, in preliminary studies, with disease susceptibility, especially among Orientals. HLA gene probing is potentially an even more precise tool than monoclonal antibodies for the study of MHC-related disease susceptibilities. Initial work in our laboratory has resulted in the production of probes with specificity for HLA-B locus genes and current efforts are directed toward the derivation of B27 allele-specific probes. It seems likely that, when such probes are applied to B27-positive individuals, complexity in addition to the B27M2 variants will be revealed. Yet to be defined is the mechanism behind the association between B27 and AS. Is the association causal for disease, or is B27 indeed just a marker for other pathogenic factors somehow linked to it? Available evidence points to both causal and linked roles for B27 in ankylosing spondylitis. Products of both HLA and non-HLA gene families may interact with infectious disease pathogens in susceptible individuals to produce a disorder which may not be specific in its association with any one pathogenic factor." @default.
- W2010336457 created "2016-06-24" @default.
- W2010336457 creator A5001436597 @default.
- W2010336457 creator A5034001543 @default.
- W2010336457 creator A5087811468 @default.
- W2010336457 date "1985-08-01" @default.
- W2010336457 modified "2023-09-23" @default.
- W2010336457 title "Molecular Variants of the HLA-B27 Antigen in Healthy Individuals and Patients with Spondylarthropathies" @default.
- W2010336457 cites W1970960440 @default.
- W2010336457 cites W1971754293 @default.
- W2010336457 cites W1971971659 @default.
- W2010336457 cites W1978593877 @default.
- W2010336457 cites W1978968014 @default.
- W2010336457 cites W1991585112 @default.
- W2010336457 cites W1996143093 @default.
- W2010336457 cites W1998975537 @default.
- W2010336457 cites W2006117036 @default.
- W2010336457 cites W2006255263 @default.
- W2010336457 cites W2016635355 @default.
- W2010336457 cites W2017255424 @default.
- W2010336457 cites W2030522563 @default.
- W2010336457 cites W2035837269 @default.
- W2010336457 cites W2036528299 @default.
- W2010336457 cites W2040329593 @default.
- W2010336457 cites W2042564520 @default.
- W2010336457 cites W2043819941 @default.
- W2010336457 cites W2049884195 @default.
- W2010336457 cites W2052781280 @default.
- W2010336457 cites W2053686485 @default.
- W2010336457 cites W2067442767 @default.
- W2010336457 cites W2070585645 @default.
- W2010336457 cites W2072541653 @default.
- W2010336457 cites W2078642485 @default.
- W2010336457 cites W2079628350 @default.
- W2010336457 cites W2084628493 @default.
- W2010336457 cites W2085875002 @default.
- W2010336457 cites W2086813071 @default.
- W2010336457 cites W2095653247 @default.
- W2010336457 cites W2098641743 @default.
- W2010336457 cites W2142959567 @default.
- W2010336457 cites W2167418901 @default.
- W2010336457 cites W2171386105 @default.
- W2010336457 cites W2266468526 @default.
- W2010336457 cites W2338072779 @default.
- W2010336457 cites W2339656756 @default.
- W2010336457 cites W2413045917 @default.
- W2010336457 doi "https://doi.org/10.1111/j.1600-065x.1985.tb01138.x" @default.
- W2010336457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2412952" @default.
- W2010336457 hasPublicationYear "1985" @default.
- W2010336457 type Work @default.
- W2010336457 sameAs 2010336457 @default.
- W2010336457 citedByCount "14" @default.
- W2010336457 crossrefType "journal-article" @default.
- W2010336457 hasAuthorship W2010336457A5001436597 @default.
- W2010336457 hasAuthorship W2010336457A5034001543 @default.
- W2010336457 hasAuthorship W2010336457A5087811468 @default.
- W2010336457 hasConcept C104317684 @default.
- W2010336457 hasConcept C142724271 @default.
- W2010336457 hasConcept C147483822 @default.
- W2010336457 hasConcept C180754005 @default.
- W2010336457 hasConcept C188280979 @default.
- W2010336457 hasConcept C195616568 @default.
- W2010336457 hasConcept C203014093 @default.
- W2010336457 hasConcept C207936829 @default.
- W2010336457 hasConcept C2777402515 @default.
- W2010336457 hasConcept C2778091532 @default.
- W2010336457 hasConcept C2779134260 @default.
- W2010336457 hasConcept C2909797730 @default.
- W2010336457 hasConcept C54355233 @default.
- W2010336457 hasConcept C71924100 @default.
- W2010336457 hasConcept C84597430 @default.
- W2010336457 hasConcept C86803240 @default.
- W2010336457 hasConceptScore W2010336457C104317684 @default.
- W2010336457 hasConceptScore W2010336457C142724271 @default.
- W2010336457 hasConceptScore W2010336457C147483822 @default.
- W2010336457 hasConceptScore W2010336457C180754005 @default.
- W2010336457 hasConceptScore W2010336457C188280979 @default.
- W2010336457 hasConceptScore W2010336457C195616568 @default.
- W2010336457 hasConceptScore W2010336457C203014093 @default.
- W2010336457 hasConceptScore W2010336457C207936829 @default.
- W2010336457 hasConceptScore W2010336457C2777402515 @default.
- W2010336457 hasConceptScore W2010336457C2778091532 @default.
- W2010336457 hasConceptScore W2010336457C2779134260 @default.
- W2010336457 hasConceptScore W2010336457C2909797730 @default.
- W2010336457 hasConceptScore W2010336457C54355233 @default.
- W2010336457 hasConceptScore W2010336457C71924100 @default.
- W2010336457 hasConceptScore W2010336457C84597430 @default.
- W2010336457 hasConceptScore W2010336457C86803240 @default.
- W2010336457 hasLocation W20103364571 @default.
- W2010336457 hasLocation W20103364572 @default.
- W2010336457 hasOpenAccess W2010336457 @default.
- W2010336457 hasPrimaryLocation W20103364571 @default.
- W2010336457 hasRelatedWork W1507668730 @default.
- W2010336457 hasRelatedWork W1939941513 @default.
- W2010336457 hasRelatedWork W1963787330 @default.
- W2010336457 hasRelatedWork W1973088414 @default.
- W2010336457 hasRelatedWork W1996607800 @default.
- W2010336457 hasRelatedWork W2039801769 @default.
- W2010336457 hasRelatedWork W2070083128 @default.
- W2010336457 hasRelatedWork W2098250589 @default.