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- W2010337499 abstract "Decrease in arterial blood pressure is a prominent adverse reaction during propofol (Disoprivan; AstraZeneca K.K., Osaka, Japan) sedation. The purpose of this prospective randomized study was to explore the effects of nitrous oxide (N2O) on the hypotensive response during propofol sedation.Twenty-six healthy volunteers received intravenous sedation with propofol alone (group P, n = 13) or a combined technique using 20% N2O and propofol (group N + P, n = 13). Propofol was administered by a target-controlled infusion system to attain and maintain a plasma propofol concentration of 1.5 μg/mL. Hemodynamic and autonomic parameters were measured.Mean arterial pressure decreased in both groups, the hypotensive response in group N + P being significantly smaller than in group P. Reduction in the low-frequency power of systolic blood pressure variability, indicative of sympathetic nervous activity, was also smaller in group N + P than in group P.Addition of N2O to propofol sedation can attenuate the hypotensive effect of propofol." @default.
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- W2010337499 date "2007-03-01" @default.
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- W2010337499 title "Protein interaction network for pluripotency of ES cells: Possible clues to organization of self-renewal machinery in other stem cells" @default.
- W2010337499 doi "https://doi.org/10.1016/j.bcmd.2006.10.103" @default.
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