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- W2010338621 abstract "Significance Pathogenic bacteria that experience limited nutrient availability in the host gut have evolved sophisticated systems to catabolize N -acetylneuraminic acid (Neu5Ac; sialic acid). This study reports the structural analysis of NanR, a repressor of the N -acetylneuraminate ( nan ) genes responsible for Neu5Ac catabolism, complexed with its regulatory ligand, N -acetylmannosamine 6-phosphate (ManNAc-6P). The interaction between NanR and the nan promoter is alleviated by the ManNAc-6P–mediated relocation of residues in the ligand-binding domain of NanR, which subsequently relieves the repressive effect of NanR and induces the transcription of nan genes. These events are required for survival and for Vibrio vulnificus pathogenesis." @default.
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- W2010338621 date "2013-07-05" @default.
- W2010338621 modified "2023-10-16" @default.
- W2010338621 title "Structural insights into the regulation of sialic acid catabolism by the <i>Vibrio vulnificus</i> transcriptional repressor NanR" @default.
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- W2010338621 doi "https://doi.org/10.1073/pnas.1302859110" @default.
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