Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010338957> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2010338957 endingPage "1211" @default.
- W2010338957 startingPage "1206" @default.
- W2010338957 abstract "Spirohydantoin mustard (I) is a rationally designed anti-tumor agent with substantial in vivo activity against intracranially implanted tumors in mice. However, hydrolysis of I was much faster than that of mechlorethamine hydrochloride or melphalan, two parenterally administered mustards. The hydrolysis products of I were identified by GC-MS of their silylated derivatives. The decomposition of I (at 25 degrees in 10% dimethylacetamide at pH 4-6), as monitored by GLC was pseudo first-order. The half-life of I ranged from 20 min at pH 4.0 to 14 min at pH 6.0. Nonionic surfactants enhanced the stability of I, but this effect was diminished at lower pH, presumably due to decreased solubility of I in the micelle as more drug was protonated. Several dilute parenterally suitable solvents exhibited no marked effect on the hydrolysis of I. The drug was most stable in a 10% fat emulsion system where the time for 10% decomposition of I was 49 +/- 5 min. Plots of the concentration of I versus time were linear indicating the disappearance was zero order in the 10% fat emulsion system." @default.
- W2010338957 created "2016-06-24" @default.
- W2010338957 creator A5011702253 @default.
- W2010338957 creator A5025186925 @default.
- W2010338957 creator A5042689207 @default.
- W2010338957 date "1982-11-01" @default.
- W2010338957 modified "2023-10-09" @default.
- W2010338957 title "The Hydrolysis of Spirohydantoin Mustard" @default.
- W2010338957 cites W1497669653 @default.
- W2010338957 cites W1963628349 @default.
- W2010338957 cites W2013392474 @default.
- W2010338957 cites W2023597538 @default.
- W2010338957 cites W2052099534 @default.
- W2010338957 cites W2053406821 @default.
- W2010338957 cites W2058566960 @default.
- W2010338957 cites W2070324064 @default.
- W2010338957 cites W2073597314 @default.
- W2010338957 cites W2150365687 @default.
- W2010338957 doi "https://doi.org/10.1002/jps.2600711106" @default.
- W2010338957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7175709" @default.
- W2010338957 hasPublicationYear "1982" @default.
- W2010338957 type Work @default.
- W2010338957 sameAs 2010338957 @default.
- W2010338957 citedByCount "11" @default.
- W2010338957 countsByYear W20103389572016 @default.
- W2010338957 crossrefType "journal-article" @default.
- W2010338957 hasAuthorship W2010338957A5011702253 @default.
- W2010338957 hasAuthorship W2010338957A5025186925 @default.
- W2010338957 hasAuthorship W2010338957A5042689207 @default.
- W2010338957 hasConcept C11268172 @default.
- W2010338957 hasConcept C124681953 @default.
- W2010338957 hasConcept C13965031 @default.
- W2010338957 hasConcept C145148216 @default.
- W2010338957 hasConcept C150903083 @default.
- W2010338957 hasConcept C155574463 @default.
- W2010338957 hasConcept C178790620 @default.
- W2010338957 hasConcept C184651966 @default.
- W2010338957 hasConcept C185592680 @default.
- W2010338957 hasConcept C207001950 @default.
- W2010338957 hasConcept C2776460385 @default.
- W2010338957 hasConcept C2777921878 @default.
- W2010338957 hasConcept C2778123984 @default.
- W2010338957 hasConcept C2780471494 @default.
- W2010338957 hasConcept C30095370 @default.
- W2010338957 hasConcept C43617362 @default.
- W2010338957 hasConcept C86803240 @default.
- W2010338957 hasConcept C94412978 @default.
- W2010338957 hasConceptScore W2010338957C11268172 @default.
- W2010338957 hasConceptScore W2010338957C124681953 @default.
- W2010338957 hasConceptScore W2010338957C13965031 @default.
- W2010338957 hasConceptScore W2010338957C145148216 @default.
- W2010338957 hasConceptScore W2010338957C150903083 @default.
- W2010338957 hasConceptScore W2010338957C155574463 @default.
- W2010338957 hasConceptScore W2010338957C178790620 @default.
- W2010338957 hasConceptScore W2010338957C184651966 @default.
- W2010338957 hasConceptScore W2010338957C185592680 @default.
- W2010338957 hasConceptScore W2010338957C207001950 @default.
- W2010338957 hasConceptScore W2010338957C2776460385 @default.
- W2010338957 hasConceptScore W2010338957C2777921878 @default.
- W2010338957 hasConceptScore W2010338957C2778123984 @default.
- W2010338957 hasConceptScore W2010338957C2780471494 @default.
- W2010338957 hasConceptScore W2010338957C30095370 @default.
- W2010338957 hasConceptScore W2010338957C43617362 @default.
- W2010338957 hasConceptScore W2010338957C86803240 @default.
- W2010338957 hasConceptScore W2010338957C94412978 @default.
- W2010338957 hasIssue "11" @default.
- W2010338957 hasLocation W20103389571 @default.
- W2010338957 hasLocation W20103389572 @default.
- W2010338957 hasOpenAccess W2010338957 @default.
- W2010338957 hasPrimaryLocation W20103389571 @default.
- W2010338957 hasRelatedWork W1571167194 @default.
- W2010338957 hasRelatedWork W1588201382 @default.
- W2010338957 hasRelatedWork W1993510903 @default.
- W2010338957 hasRelatedWork W2021444944 @default.
- W2010338957 hasRelatedWork W2021989727 @default.
- W2010338957 hasRelatedWork W2044747892 @default.
- W2010338957 hasRelatedWork W2070272790 @default.
- W2010338957 hasRelatedWork W2081371352 @default.
- W2010338957 hasRelatedWork W2089447279 @default.
- W2010338957 hasRelatedWork W945805037 @default.
- W2010338957 hasVolume "71" @default.
- W2010338957 isParatext "false" @default.
- W2010338957 isRetracted "false" @default.
- W2010338957 magId "2010338957" @default.
- W2010338957 workType "article" @default.