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- W2010343742 abstract "Preincubation of rat adrenocortical cells with lovastatin inhibits high density lipoprotein (HDL3) interaction with rat adrenocortical cells in a dose- and time-dependent fashion. Lovastatin causes a decrease in the number of binding sites and a moderate increase in the affinity of HDL binding to cells. Lovastatin also produced a dose- and time-dependent inhibition of cholesterol synthesis in these cells. Dose-dependence, but not time-dependence, of the inhibition of cholesterol synthesis, correlates with that of HDL binding (r = 0.91, P < 0.004). Incubation of cells with lovastatin for up to 24 h does not change their free or total cholesterol content. The inhibitory effect was apparently not due to a modification of HDL by lovastatin. These results indicate that lovastatin causes a down-regulation of HDL binding sites on cultured rat adrenocortical cells." @default.
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- W2010343742 date "1991-06-01" @default.
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- W2010343742 title "Effect of lovastatin on the interaction between high density lipoprotein and cultured rat adrenocortical cells" @default.
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- W2010343742 doi "https://doi.org/10.1016/0021-9150(91)90086-i" @default.
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