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- W2010344733 abstract "Supramolecular and bio-supramolecular host assisted pKa shift of biologically relevant acidic guests, warfarin and coumarin 343, has been monitored using both steady-state and time resolved fluorescence spectroscopy. The anion receptors present in sub-domain IIA of human serum albumin (HSA) stabilize the anionic form of the guest and thereby shift pKa towards acidic range. On the other hand, the preferential binding of the neutral form of guests in the non-polar hydrophobic cavity of β-cyclodextrin results in up-shifted pKa. This shifting of pKa of drugs like warfarin, etc., whose therapeutic activity depends on the position of the acid-base equilibrium in human system, is of great importance in pharmacokinetics. The release of the active form of such drugs from macrocyclic carrier and subsequent distribution through the carrier protein should depend on the modulation of the overall pKa window brought about by the encapsulation in these hosts. Present work also suggests that properly optimized encapsulation in appropriate receptor pocket can enhance the bioavailability of drugs. This work also opens up the possibility to use HSA as encapsulator, instead of traditional cyclodextrins or other polymeric hosts, since such system may overcome toxicity as well as biocompatibility issues." @default.
- W2010344733 created "2016-06-24" @default.
- W2010344733 creator A5014513238 @default.
- W2010344733 creator A5026901281 @default.
- W2010344733 date "2014-01-01" @default.
- W2010344733 modified "2023-09-27" @default.
- W2010344733 title "Effect of encapsulation in the anion receptor pocket of sub-domain IIA of human serum albumin on the modulation of pKa of warfarin and structurally similar acidic guests: A possible implication on biological activity" @default.
- W2010344733 cites W1518136555 @default.
- W2010344733 cites W1951485886 @default.
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- W2010344733 cites W1971666978 @default.
- W2010344733 cites W1972718557 @default.
- W2010344733 cites W1973238993 @default.
- W2010344733 cites W1978710898 @default.
- W2010344733 cites W1978929238 @default.
- W2010344733 cites W1979862336 @default.
- W2010344733 cites W1981156961 @default.
- W2010344733 cites W1983899252 @default.
- W2010344733 cites W1986952328 @default.
- W2010344733 cites W1988291078 @default.
- W2010344733 cites W1990275726 @default.
- W2010344733 cites W1992465391 @default.
- W2010344733 cites W1992604383 @default.
- W2010344733 cites W2006568020 @default.
- W2010344733 cites W2009906913 @default.
- W2010344733 cites W2011290467 @default.
- W2010344733 cites W2012309950 @default.
- W2010344733 cites W2015045485 @default.
- W2010344733 cites W2017165985 @default.
- W2010344733 cites W2019327448 @default.
- W2010344733 cites W2020673935 @default.
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- W2010344733 cites W2035457511 @default.
- W2010344733 cites W2039104539 @default.
- W2010344733 cites W2044405324 @default.
- W2010344733 cites W2050503887 @default.
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- W2010344733 cites W2069247236 @default.
- W2010344733 cites W2069635793 @default.
- W2010344733 cites W2073394985 @default.
- W2010344733 cites W2073626515 @default.
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- W2010344733 cites W2083189685 @default.
- W2010344733 cites W2085563939 @default.
- W2010344733 cites W2086589276 @default.
- W2010344733 cites W2086638305 @default.
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- W2010344733 cites W2133297073 @default.
- W2010344733 cites W2134586168 @default.
- W2010344733 cites W2142786818 @default.
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- W2010344733 cites W2163153095 @default.
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- W2010344733 cites W2313350426 @default.
- W2010344733 cites W2333059703 @default.
- W2010344733 cites W2333272203 @default.
- W2010344733 cites W2949195838 @default.
- W2010344733 cites W2949466603 @default.
- W2010344733 cites W2952213065 @default.
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- W2010344733 doi "https://doi.org/10.1016/j.jphotobiol.2013.10.013" @default.
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