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- W2010348528 abstract "The diagnosis of myeloma requires the presence of 10% or more clonal plasma cells on bone marrow examination or of a biopsy-proven plasmacytoma along with evidence of end-organ damage that can be attributed to the underlying plasma cell disorder [1]. The above-mentioned case had >90% neoplastic plasma cells in the bone marrow and a significant anaemia as a result of the bone marrow infiltration. Cytological features of myeloma cells can be highly variable. They include tumors with mature and benign appearing plasma cells; small lymphoid-like cells; atypical but differentiated plasmacytic cells; blastic cells with high nucleus: cytoplasmic ratio and fine chromatin; large cells with immunoblastic features and highly pleomorphic forms. The current case showed immunoblastic features and pleomorphism. Differential diagnosis varies as per the cytological features and includes benign/reactive plasma cell infiltrates, small cell lymphomas, large cell lymphomas, metastatic carcinomas, and other metastatic tumors. Documentation of the expression of immunoglobulin either at protein level or at RNA level confirms the B-cell/plasma cell lineage of these tumors. Expression of CD138, CD79a, and CD56 is helpful in the diagnosis of myeloma, though carcinomas can express CD138 and those with neuroendocrine features can express CD56. Expression of cyclin D1 is noted in 40% of cases and is a very helpful feature in the diagnosis and follow-up of myeloma on bone marrow trephine biopsies [2]. Cases with uniform and strong expression of cyclin D1 are associated CCND1 translocation." @default.
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- W2010348528 date "2011-04-26" @default.
- W2010348528 modified "2023-09-25" @default.
- W2010348528 title "Bone marrow trephine biopsy findings in a case of myeloma with large immunoblast-like cells" @default.
- W2010348528 cites W2058806884 @default.
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- W2010348528 doi "https://doi.org/10.1002/ajh.22000" @default.
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