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- W2010362272 abstract "Liquid chromatographic (HPLC) methods with fluorescence detection at different wavelengths were developed for measuraments of retinoic acids (13-cis and all-trans) in pharmaceutical dosage forms and components of ‘retinoid solution’ (all-trans retinoic acid, vitamin A palmitate and β-carotene), a galenical of ‘Di Bella therapy’, using reversed phase columns under isocratic conditions. The stability of all-trans retinoic acid in cream and all-trans retinoic acid and vitamin A palmitate in ‘retinoid solution’ was investigated. Solid-phase extraction (SPE), using C18 sorbent was applied to the analysis of retinoic acids (9-cis, 13-cis and all-trans) in the ‘retinoid solution’ to obtain a practical and reliable sample clean-up. The results showed that these preparations (cream and solution) can be conveniently stored in the dark (t.a. or 2–8°C); under these conditions about 86–87% of the all-trans retinoic acid initial concentration in both formulations and about 73–78% of vitamin A palmitate in the ‘retinoid solution’ remained after 90 days, while under sunlight exposure rapid degradation of the drugs was observed." @default.
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- W2010362272 date "1986-01-01" @default.
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- W2010362272 title "Microdetermination of vitamin A in human plasma using high-performance liquid chromatography with fluorescence detection" @default.
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- W2010362272 doi "https://doi.org/10.1016/s0378-4347(00)83531-8" @default.
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