Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010363079> ?p ?o ?g. }
- W2010363079 endingPage "1500" @default.
- W2010363079 startingPage "1486" @default.
- W2010363079 abstract "Missense point mutations in the TP53 gene are frequent genetic alterations in human tumor tissue and cell lines derived thereof. Mutant p53 (mutp53) proteins have lost sequence-specific DNA binding, but have retained the ability to interact in a structure-selective manner with non-B DNA and to act as regulators of transcription. To identify functional binding sites of mutp53, we established a small library of genomic sequences bound by p53 R273H in U251 human glioblastoma cells using chromatin immunoprecipitation (ChIP). Mutp53 binding to isolated DNA fragments confirmed the specificity of the ChIP. The mutp53 bound DNA sequences are rich in repetitive DNA elements, which are dispersed over non-coding DNA regions. Stable down-regulation of mutp53 expression strongly suggested that mutp53 binding to genomic DNA is functional. We identified the PPARGC1A and FRMD5 genes as p53 R273H targets regulated by binding to intronic and intra-genic sequences. We propose a model that attributes the oncogenic functions of mutp53 to its ability to interact with intronic and intergenic non-B DNA sequences and modulate gene transcription via re-organization of chromatin." @default.
- W2010363079 created "2016-06-24" @default.
- W2010363079 creator A5004433955 @default.
- W2010363079 creator A5017244731 @default.
- W2010363079 creator A5017601514 @default.
- W2010363079 creator A5034157471 @default.
- W2010363079 creator A5038159102 @default.
- W2010363079 creator A5059942450 @default.
- W2010363079 creator A5078036095 @default.
- W2010363079 creator A5089878731 @default.
- W2010363079 creator A5091514112 @default.
- W2010363079 date "2009-01-12" @default.
- W2010363079 modified "2023-10-06" @default.
- W2010363079 title "Modulation of gene expression in U251 glioblastoma cells by binding of mutant p53 R273H to intronic and intergenic sequences" @default.
- W2010363079 cites W1484529414 @default.
- W2010363079 cites W153114641 @default.
- W2010363079 cites W1569314672 @default.
- W2010363079 cites W1644172598 @default.
- W2010363079 cites W1870851597 @default.
- W2010363079 cites W1927421238 @default.
- W2010363079 cites W1964178865 @default.
- W2010363079 cites W1964933038 @default.
- W2010363079 cites W1965335659 @default.
- W2010363079 cites W1965581435 @default.
- W2010363079 cites W1975148552 @default.
- W2010363079 cites W1976169445 @default.
- W2010363079 cites W1986076152 @default.
- W2010363079 cites W1988332041 @default.
- W2010363079 cites W1988894877 @default.
- W2010363079 cites W1989776223 @default.
- W2010363079 cites W1993414761 @default.
- W2010363079 cites W1995177916 @default.
- W2010363079 cites W1998271864 @default.
- W2010363079 cites W1999122619 @default.
- W2010363079 cites W2000704741 @default.
- W2010363079 cites W2007978091 @default.
- W2010363079 cites W2009071546 @default.
- W2010363079 cites W2010355875 @default.
- W2010363079 cites W2010643258 @default.
- W2010363079 cites W2010957401 @default.
- W2010363079 cites W2013064216 @default.
- W2010363079 cites W2013969883 @default.
- W2010363079 cites W2016733318 @default.
- W2010363079 cites W2019136439 @default.
- W2010363079 cites W2032109237 @default.
- W2010363079 cites W2033877698 @default.
- W2010363079 cites W2038774969 @default.
- W2010363079 cites W2038783205 @default.
- W2010363079 cites W2041383414 @default.
- W2010363079 cites W2042484101 @default.
- W2010363079 cites W2044782567 @default.
- W2010363079 cites W2049107191 @default.
- W2010363079 cites W2054293105 @default.
- W2010363079 cites W2058737236 @default.
- W2010363079 cites W2063125022 @default.
- W2010363079 cites W2065398612 @default.
- W2010363079 cites W2069791672 @default.
- W2010363079 cites W2072894498 @default.
- W2010363079 cites W2077150554 @default.
- W2010363079 cites W2077230345 @default.
- W2010363079 cites W2089106375 @default.
- W2010363079 cites W2091664490 @default.
- W2010363079 cites W2094957670 @default.
- W2010363079 cites W2097207775 @default.
- W2010363079 cites W2101657563 @default.
- W2010363079 cites W2104243200 @default.
- W2010363079 cites W2106646268 @default.
- W2010363079 cites W2108017320 @default.
- W2010363079 cites W2114570899 @default.
- W2010363079 cites W2117567491 @default.
- W2010363079 cites W2118530896 @default.
- W2010363079 cites W2120303542 @default.
- W2010363079 cites W2123017921 @default.
- W2010363079 cites W2128080369 @default.
- W2010363079 cites W2129680740 @default.
- W2010363079 cites W2136145671 @default.
- W2010363079 cites W2136292095 @default.
- W2010363079 cites W2141340108 @default.
- W2010363079 cites W2148613526 @default.
- W2010363079 cites W2151794037 @default.
- W2010363079 cites W2152261934 @default.
- W2010363079 cites W2154723040 @default.
- W2010363079 cites W2156452836 @default.
- W2010363079 cites W2159479483 @default.
- W2010363079 cites W2161222316 @default.
- W2010363079 cites W2162487261 @default.
- W2010363079 cites W2170211828 @default.
- W2010363079 cites W2171407623 @default.
- W2010363079 cites W2322456862 @default.
- W2010363079 cites W4241482573 @default.
- W2010363079 doi "https://doi.org/10.1093/nar/gkn1085" @default.
- W2010363079 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2655687" @default.
- W2010363079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19139068" @default.
- W2010363079 hasPublicationYear "2009" @default.
- W2010363079 type Work @default.
- W2010363079 sameAs 2010363079 @default.
- W2010363079 citedByCount "55" @default.
- W2010363079 countsByYear W20103630792012 @default.