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• W2010366970 abstract "Most cell cycle regulation research has been conducted in model organisms representing a very small part of the eukaryotic domain. The highly divergent human pathogen Giardia intestinalis is ideal for studying the conservation of eukaryotic pathways. Although Giardia has many cell cycle regulatory components, its genome lacks all Anaphase Promoting Complex (APC) components. In the present study we show that a single mitotic cyclin in Giardia is essential for progression into mitosis. Strikingly, Gi cyclin B lacks the conserved N-terminal motif required for timely degradation mediated by the APC and ubiquitin conjugation. Expression of Gi cyclin B in fission yeast is toxic, leading to a prophase arrest, and this toxicity is suppressed by the addition of a fission yeast degradation motif. Cyclin B is degraded during mitosis in Giardia cells, but this degradation appears to be independent of the ubiquitination pathway. Other putative APC substrates, aurora and polo-like kinases, also show no evidence of ubiquitination. This is the first example of mitosis not regulated by the APC and may reflect an evolutionary ancient form of cell cycle regulation." @default.
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• W2010366970 date "2013-01-01" @default.
• W2010366970 modified "2023-10-14" @default.
• W2010366970 title "The <i>Giardia</i> cell cycle progresses independently of the Anaphase Promoting Complex" @default.
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• W2010366970 doi "https://doi.org/10.1242/jcs.121632" @default.
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