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• W2010366971 abstract "Domoic acid and related compounds isolated from a red seaweed, Chondria armata, were strongly insecticidal toward various insects and also caused contraction of the hindgut excised from American cockroaches. The contraction of the hindgut did not occur when calcium ions were removed from or when a calcium channel blocker, verapamil, was added to the incubation medium. The addition of a cysteine proteinase inhibitor, strepin P-1, partially blocked the domoic acid activity. A low concentration of domoic acid enhanced the sensitivity of the insect neuromuscular junctions to glutamic acid. These results suggest that domoic acid not only affects calcium ion transport and stimulates a calcium-dependent process that regulates the release of glutamic acid from presynaptic nerve endings, but also acivates a calcium-dependent proteinase leading to generation of glutamic acid receptors on the neuromuscular postsynaptic membrane from the latent state. Proctolin, a neuropeptide of insects, also caused contraction of the hindgut. As with domoic acid, the proctolin-induced contraction did not occur without calcium ions in the incubation medium or after treatment with verapamil. It was also partially blocked by strepin P-1. Thus, proctolin is probably a natural regulator of signal transmission of the neuromuscular junctions of the insect hindgut, and domoic acid may bind to proctolin receptors to act." @default.
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• W2010366971 date "1987-05-01" @default.
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• W2010366971 title "Neuromuscular action of insecticidal domoic acid on the American cockroach" @default.
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• W2010366971 doi "https://doi.org/10.1016/0048-3575(87)90116-7" @default.
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