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- W2010368097 endingPage "184" @default.
- W2010368097 startingPage "175" @default.
- W2010368097 abstract "Although degeneration of the intervertebral disk has historically been described as a misbalance between anabolic and catabolic factors, the role of inflammatory mediators has long been neglected. However, past research clearly indicates that inflammatory mediators such as interleukin (IL)-1β, IL-6, IL-8 and tumor necrosis factor-α are expressed at higher levels in diseased intervertebral disks. Both disk cells as well as invading macrophages can be the source of the detected cytokines. Importantly, occurrence of inflammatory mediators in the disk can worsen the progress of degeneration by inducing the expression of matrix degrading enzymes as well as by inhibiting extracellular matrix synthesis. In addition, inflammatory mediators play a crucial role in pain development during intervertebral disk herniation (i.e., sciatica) and disk degeneration (i.e., discogenic pain). This review provides information on the most relevant inflammatory mediators during different types of disk diseases and explains how these factors can induce disk degeneration and the development of discogenic and sciatic/radiculopathic pain." @default.
- W2010368097 created "2016-06-24" @default.
- W2010368097 creator A5028696068 @default.
- W2010368097 creator A5091041617 @default.
- W2010368097 date "2013-05-21" @default.
- W2010368097 modified "2023-10-17" @default.
- W2010368097 title "Inflammatory Mediators in Intervertebral Disk Degeneration and Discogenic Pain" @default.
- W2010368097 cites W1453797714 @default.
- W2010368097 cites W1492293685 @default.
- W2010368097 cites W1505597474 @default.
- W2010368097 cites W1533084563 @default.
- W2010368097 cites W1547532158 @default.
- W2010368097 cites W1829237824 @default.
- W2010368097 cites W1964006302 @default.
- W2010368097 cites W1964195533 @default.
- W2010368097 cites W1964802599 @default.
- W2010368097 cites W1968320346 @default.
- W2010368097 cites W1976429655 @default.
- W2010368097 cites W1979264581 @default.
- W2010368097 cites W1979476725 @default.
- W2010368097 cites W1979499962 @default.
- W2010368097 cites W1981489213 @default.
- W2010368097 cites W1982755618 @default.
- W2010368097 cites W1990910525 @default.
- W2010368097 cites W1994261880 @default.
- W2010368097 cites W1996701920 @default.
- W2010368097 cites W1997676632 @default.
- W2010368097 cites W1998968944 @default.
- W2010368097 cites W2002044398 @default.
- W2010368097 cites W2007413067 @default.
- W2010368097 cites W2007502509 @default.
- W2010368097 cites W2008664564 @default.
- W2010368097 cites W2009537114 @default.
- W2010368097 cites W2012247239 @default.
- W2010368097 cites W2012808248 @default.
- W2010368097 cites W2015457336 @default.
- W2010368097 cites W2015869069 @default.
- W2010368097 cites W2017100113 @default.
- W2010368097 cites W2019275635 @default.
- W2010368097 cites W2019697400 @default.
- W2010368097 cites W2021059779 @default.
- W2010368097 cites W2022044245 @default.
- W2010368097 cites W2023452486 @default.
- W2010368097 cites W2023757453 @default.
- W2010368097 cites W2024585159 @default.
- W2010368097 cites W2024703813 @default.
- W2010368097 cites W2030604088 @default.
- W2010368097 cites W2031032117 @default.
- W2010368097 cites W2033211248 @default.
- W2010368097 cites W2035694106 @default.
- W2010368097 cites W2040626349 @default.
- W2010368097 cites W2040834574 @default.
- W2010368097 cites W2040939772 @default.
- W2010368097 cites W2044146377 @default.
- W2010368097 cites W2044474568 @default.
- W2010368097 cites W2046080925 @default.
- W2010368097 cites W2046429270 @default.
- W2010368097 cites W2046654904 @default.
- W2010368097 cites W2046965922 @default.
- W2010368097 cites W2047825133 @default.
- W2010368097 cites W2047997540 @default.
- W2010368097 cites W2049568701 @default.
- W2010368097 cites W2049583905 @default.
- W2010368097 cites W2050408761 @default.
- W2010368097 cites W2051114553 @default.
- W2010368097 cites W2055395294 @default.
- W2010368097 cites W2058417962 @default.
- W2010368097 cites W2058638984 @default.
- W2010368097 cites W2059483506 @default.
- W2010368097 cites W2060861339 @default.
- W2010368097 cites W2061456864 @default.
- W2010368097 cites W2062203127 @default.
- W2010368097 cites W2065000678 @default.
- W2010368097 cites W2066429128 @default.
- W2010368097 cites W2067008261 @default.
- W2010368097 cites W2068747348 @default.
- W2010368097 cites W2072787498 @default.
- W2010368097 cites W2076047801 @default.
- W2010368097 cites W2076651648 @default.
- W2010368097 cites W2080350228 @default.
- W2010368097 cites W2082480800 @default.
- W2010368097 cites W2084841940 @default.
- W2010368097 cites W2086627361 @default.
- W2010368097 cites W2087452992 @default.
- W2010368097 cites W2089797087 @default.
- W2010368097 cites W2090157199 @default.
- W2010368097 cites W2090894469 @default.
- W2010368097 cites W2091025894 @default.
- W2010368097 cites W2091198355 @default.
- W2010368097 cites W2093054125 @default.
- W2010368097 cites W2099946862 @default.
- W2010368097 cites W2105899367 @default.
- W2010368097 cites W2111529885 @default.
- W2010368097 cites W2113855782 @default.
- W2010368097 cites W2123590414 @default.
- W2010368097 cites W2126153483 @default.
- W2010368097 cites W2128431867 @default.
- W2010368097 cites W2128885628 @default.