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• W2010368774 abstract "Le cancer de la thyroïde est un cancer peu fréquent. La biologie moléculaire joue un rôle capital dans son développement. La chimiothérapie a montré des résultats peu satisfaisants aux stades avancés où la chirurgie et l’iodothérapie ne sont plus de mise. Ces dix dernières années ont été marquées par des avancées majeures dans la connaissance des particularités moléculaires de ce cancer et leurs corrélations thérapeutiques, de même des essais cliniques se sont intéressés au traitement de cette pathologie aux stades métastatiques et ont permis de développer un panel thérapeutique important ciblant l’angiogenèse, les mutations fréquemment rencontrées dans ce cancer : RET, BRAF, RAS. Il s’agit du motésanib, axitinib, sunitinib, pazopanib, vandétanib, cabozantinib et sorafénib. Ces trois dernières molécules ont déjà obtenu l’autorisation de mise sur le marché. Dans cette revue, nous allons mettre le point sur les caractéristiques oncogénétiques des carcinomes thyroïdiens ainsi que les nouvelles thérapies ciblées chez les patients réfractaires aux traitements usuels. Thyroid cancer is an uncommon cancer. Molecular biology plays a vital role in its development. Chemotherapy showed unsatisfactory results in advanced stages where surgery and iodine therapy are not appropriate. These last ten years have been marked by a major advance in understanding the molecular features of this cancer and therapeutic correlations, moreover, clinical trials have focused on the treatment of this disease on metastatic stages and led to a significant therapeutic panel targeting angiogenesis, mutations frequently found in cervical cancer: RET, BRAF, RAS… these are the motesanib, axitinib, sunitinib, pazopanib, vandetanib, cabozotinib and sorafenib. The last three molecules have already the autorisation of FDA and EMA. In this review, we will put the item on oncogenetic characteristics of thyroid carcinoma as well as new targeted therapies in patients refractory to conventional treatment." @default.
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• W2010368774 date "2015-02-01" @default.
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• W2010368774 title "Les thérapies ciblées dans le cancer de la thyroïde : vers un traitement personnalisé ?" @default.
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• W2010368774 doi "https://doi.org/10.1016/j.patbio.2014.11.003" @default.
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