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- W2010373805 abstract "Abstract For the first time, 13 C NMR signals are shown from 13 C‐en‐riched, low‐level tricarboxylic acid (TCA) cycle intermediates from extracts of normal cardiac tissue. As the low tissue content of the key intermediates α‐ketoglutarate (α‐KG) and succinate (SUC) in normal, well perfused tissues has until now precluded direct NMR detection from intact tissues and tissue extracts, 13 C NMR signal from glutamate has generally been used to infer the isotopomer patterns of intermediates that are in chemical exchange with glutamate. However, the required assumptions regarding intracellular compartmentation for such indirect analysis have not been previously tested, as glutamate is largely cytosolic while the TCA cycle enzymes are located in the mitochondria. Chromatographic isolation of α‐KG and SUC from heart tissue extracts allowed isotopomer analysis to be performed for comparison with that of glutamate. At steady state, a direct relationship between glutamate and α‐ketoglutarate isotopomers was found, but succinate isotopomers matched those of glutamate only in hearts that displayed negligible contributions from the oxidation of unla‐beled endogenous carbon sources." @default.
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- W2010373805 title "Multiplet structure of13C NMR signal from glutamate and direct detection of tricarboxylic acid (TCA) cycle intermediates" @default.
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- W2010373805 doi "https://doi.org/10.1002/mrm.1910350203" @default.
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