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• W2010374191 abstract "The fluidity of the plasma membrane is thought to play a role in the activation of blood platelets. We investigated the lateral diffusion of the lipophilic probe 1,1′‐ditetradecyl‐3,3,3′,3′‐tetramethylindocarbocyanine perchlorate (DiIC 14 ) and derivatives in the plasma membrane of the megakaryoblast MEG‐01 by fluorescence recovery after photobleaching. The lateral diffusion coefficient ( D ) of DiIC 14 in an unstimulated cell was (3.53±0.06)×10 −9 cm 2 /s with a mobile fraction of 75%. Similar data were found with DiIC 12 and DiIC 18 , but lipophilic probes specific for the outer leaflet showed a slower diffusion with a D value of (2.99±0.31)×10 ‐9 cm 2 /s and a mobile fraction of 58%. Stimulation with platelet‐activating agents decreased the diffusion of DiIC 14 within 2 min, but left the mobile fraction unchanged. Signal processing was required for the decrease in D as D‐Phenylalanyl‐L‐prolyl‐L‐arginyl‐chloromethane‐treated thrombin, which binds normally to the thrombin receptor but fails to activate the cell, had no effect. The decrease in D was accompanied by an increase in cytosolic Ca 2+ content, [Ca 2+ ] i , and studies using different concentrations of thrombin, the Ca 2+ chelator 1,2‐bis(2‐aminophenoxy)ethane‐N,N,N′,N′‐tetraacetic acid acetoxymethylester and the Ca 2+ ionophore ionomycin revealed that lipid mobilty in the plasma membrane is regulated by Ca 2+ . In contrast, treatments thought to interfere with the mobility of membrane proteins had little effect. We conclude that the rigidification of the plasma membrane during cell activation is caused by an increase in [Ca 2+ ] i and is therefore a late event and might only contribute to signal transduction at steps downstream of the mobilization/influx of Ca 2+ ." @default.
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• W2010374191 date "1994-09-01" @default.
• W2010374191 modified "2023-10-18" @default.
• W2010374191 title "Cytosolic Calcium Ions Regulate Lipid Mobility in the Plasma Membrane of the Human Megakaryoblastic Cell Line MEG-01" @default.
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• W2010374191 doi "https://doi.org/10.1111/j.1432-1033.1994.00423.x" @default.
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