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• W2010381644 endingPage "73" @default.
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• W2010381644 abstract "Macrophage death in advanced atherosclerosis promotes necrosis and plaque destabilization. A likely cause of macrophage death is accumulation of free cholesterol (FC) in the ER, leading to activation of the unfolded protein response (UPR) and C/EBP homologous protein (CHOP)–induced apoptosis. Here we show that p38 MAPK signaling is necessary for CHOP induction and apoptosis. Additionally, two other signaling pathways must cooperate with p38-CHOP to effect apoptosis. One involves the type A scavenger receptor (SRA). As evidence, FC loading by non-SRA mechanisms activates p38 and CHOP, but not apoptosis unless the SRA is engaged. The other pathway involves c-Jun NH2-terminal kinase (JNK)2, which is activated by cholesterol trafficking to the ER, but is independent of CHOP. Thus, FC-induced apoptosis requires cholesterol trafficking to the ER, which triggers p38-CHOP and JNK2, and engagement of the SRA. These findings have important implications for understanding how the UPR, MAPKs, and the SRA might conspire to cause macrophage death, lesional necrosis, and plaque destabilization in advanced atherosclerotic lesions." @default.
• W2010381644 created "2016-06-24" @default.
• W2010381644 creator A5023263699 @default.
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• W2010381644 creator A5078662102 @default.
• W2010381644 creator A5085682671 @default.
• W2010381644 date "2005-10-03" @default.
• W2010381644 modified "2023-10-14" @default.
• W2010381644 title "Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor" @default.
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• W2010381644 doi "https://doi.org/10.1083/jcb.200502078" @default.
• W2010381644 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2171235" @default.
• W2010381644 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16203857" @default.
• W2010381644 hasPublicationYear "2005" @default.
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