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- W2010384559 abstract "Four gel systems were considered to represent a differential in viscosity covering the range from ~ 15–200 P (D ∼- 0 s−1). The gel systems were based on methylcellulose (MC), carbomer and polyethylene glycols (PEG) (two gels). The effect of different gel formulations on the activity of betamethasone (increase in the intraocular pressure: IOP) and phenylephrine hydrochloride (decrease in IOP and increase in pupil diameter) was investigated. The parameters that have been utilized to assess the performance of . preparations of the two drugs were the area under (AUC) or above the curve (AAC), the maximum response (MR) time of maximum response (TMR), and duration of activity (DA). In the case of betamethasone, it was found that a 14-fold increase in viscosity (D ∼- 0 s−1) brought about a decrease in the AUC of only 10%. With phenylephrine hydrochloride the AAC (in both drug actions (IOP) or pupil diameter) is independent of the viscosity of the ophthalmic gel over the range of ~ 15–200 P (D ∼- 0 s−2)" @default.
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- W2010384559 date "1986-09-01" @default.
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- W2010384559 title "Activity of ophthalmic gels of betamethasone and phenylephrine hydrochloride in the rabbit's eye" @default.
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- W2010384559 doi "https://doi.org/10.1016/0378-5173(86)90097-9" @default.
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