Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010384927> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2010384927 endingPage "315" @default.
- W2010384927 startingPage "309" @default.
- W2010384927 abstract "Cambendazole (CBZ), fenbendazole (FBZ), oxfendazole (OFZ) and thiabendazole (TBZ) all inhibited the fumarate stimulated oxidation of NADH in Haemonchus contortus mitochondria. These observations plus the phenomenon of cross resistance to benzimidazoles suggested that the different benzimidazole anthelmintics affect parasitic helminths in a similar manner. The variation in efficiency and spectrum of activity may therefore be due to differences in their pharmacokinetic behaviour. To test this hypothesis, the magnitude and duration of concentrations of TBZ, FBZ and OFZ in plasma and other body compartments after administration were compared with their effectiveness against parasites. The effects of similar doses against benzimidazole-resistant. Trichostrongylus colubriformis and H. contortus were found to correlate with the period high plasma concentrations were maintained. Further evidence of this relationship was obtained by infusion or multiple drenching of TBZ to cattle harbouring arrested Ostertagia ostertagi larvae, so as to maintain high circulating concentrations for an extended period. This resulted in the removal of 90% of the arrested larvae, whereas TBZ as normally administered is considered quite ineffective against these larvae. These observations suggest that the spectrum and effectiveness of benzimidazoles may be improved by extending the period during which parasites are exposed to toxic concentrations." @default.
- W2010384927 created "2016-06-24" @default.
- W2010384927 creator A5012232880 @default.
- W2010384927 creator A5044846049 @default.
- W2010384927 creator A5073368410 @default.
- W2010384927 date "1978-12-01" @default.
- W2010384927 modified "2023-10-08" @default.
- W2010384927 title "Prolonged administration: A new concept for increasing the spectrum and effectiveness of anthelmintics" @default.
- W2010384927 cites W1972759137 @default.
- W2010384927 cites W2048511226 @default.
- W2010384927 cites W2069049358 @default.
- W2010384927 cites W2078497431 @default.
- W2010384927 cites W2409291732 @default.
- W2010384927 cites W2411213625 @default.
- W2010384927 doi "https://doi.org/10.1016/0304-4017(78)90017-1" @default.
- W2010384927 hasPublicationYear "1978" @default.
- W2010384927 type Work @default.
- W2010384927 sameAs 2010384927 @default.
- W2010384927 citedByCount "111" @default.
- W2010384927 countsByYear W20103849272012 @default.
- W2010384927 countsByYear W20103849272014 @default.
- W2010384927 countsByYear W20103849272015 @default.
- W2010384927 countsByYear W20103849272016 @default.
- W2010384927 countsByYear W20103849272017 @default.
- W2010384927 countsByYear W20103849272018 @default.
- W2010384927 countsByYear W20103849272020 @default.
- W2010384927 crossrefType "journal-article" @default.
- W2010384927 hasAuthorship W2010384927A5012232880 @default.
- W2010384927 hasAuthorship W2010384927A5044846049 @default.
- W2010384927 hasAuthorship W2010384927A5073368410 @default.
- W2010384927 hasConcept C140793950 @default.
- W2010384927 hasConcept C165901193 @default.
- W2010384927 hasConcept C178790620 @default.
- W2010384927 hasConcept C185592680 @default.
- W2010384927 hasConcept C21951064 @default.
- W2010384927 hasConcept C2776715052 @default.
- W2010384927 hasConcept C2776908094 @default.
- W2010384927 hasConcept C2778484023 @default.
- W2010384927 hasConcept C2779825395 @default.
- W2010384927 hasConcept C2779904531 @default.
- W2010384927 hasConcept C2781348000 @default.
- W2010384927 hasConcept C3020442560 @default.
- W2010384927 hasConcept C42972112 @default.
- W2010384927 hasConcept C71924100 @default.
- W2010384927 hasConcept C86803240 @default.
- W2010384927 hasConcept C90856448 @default.
- W2010384927 hasConcept C98274493 @default.
- W2010384927 hasConceptScore W2010384927C140793950 @default.
- W2010384927 hasConceptScore W2010384927C165901193 @default.
- W2010384927 hasConceptScore W2010384927C178790620 @default.
- W2010384927 hasConceptScore W2010384927C185592680 @default.
- W2010384927 hasConceptScore W2010384927C21951064 @default.
- W2010384927 hasConceptScore W2010384927C2776715052 @default.
- W2010384927 hasConceptScore W2010384927C2776908094 @default.
- W2010384927 hasConceptScore W2010384927C2778484023 @default.
- W2010384927 hasConceptScore W2010384927C2779825395 @default.
- W2010384927 hasConceptScore W2010384927C2779904531 @default.
- W2010384927 hasConceptScore W2010384927C2781348000 @default.
- W2010384927 hasConceptScore W2010384927C3020442560 @default.
- W2010384927 hasConceptScore W2010384927C42972112 @default.
- W2010384927 hasConceptScore W2010384927C71924100 @default.
- W2010384927 hasConceptScore W2010384927C86803240 @default.
- W2010384927 hasConceptScore W2010384927C90856448 @default.
- W2010384927 hasConceptScore W2010384927C98274493 @default.
- W2010384927 hasIssue "4" @default.
- W2010384927 hasLocation W20103849271 @default.
- W2010384927 hasOpenAccess W2010384927 @default.
- W2010384927 hasPrimaryLocation W20103849271 @default.
- W2010384927 hasRelatedWork W1964342835 @default.
- W2010384927 hasRelatedWork W1994434638 @default.
- W2010384927 hasRelatedWork W2003351912 @default.
- W2010384927 hasRelatedWork W2010384927 @default.
- W2010384927 hasRelatedWork W2271615110 @default.
- W2010384927 hasRelatedWork W2418168941 @default.
- W2010384927 hasRelatedWork W2418597179 @default.
- W2010384927 hasRelatedWork W2460680428 @default.
- W2010384927 hasRelatedWork W46638993 @default.
- W2010384927 hasRelatedWork W7740656 @default.
- W2010384927 hasVolume "4" @default.
- W2010384927 isParatext "false" @default.
- W2010384927 isRetracted "false" @default.
- W2010384927 magId "2010384927" @default.
- W2010384927 workType "article" @default.