FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010385215> ?p ?o ?g. }

• W2010385215 endingPage "e46925" @default.
• W2010385215 startingPage "e46925" @default.
• W2010385215 abstract "Herein, we describe the synthesis and pharmacological evaluation of novel N-phenylpyrazolyl-N-glycinyl-hydrazone derivatives that were designed as novel prototypes of p38 mitogen-activated protein kinase (MAPK) inhibitors. All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit tumor necrosis factor α (TNF-α production in cultured macrophages) and in vitro MAPK p38α inhibition. The two most active anti-TNF-α derivatives, (E)-2-(3-tert-butyl-1-phenyl-1H-pyrazol-5-ylamino)-N’-((4-(2-morpholinoethoxy)naphthalen-1-yl)methylene)acetohydrazide (4a) and (E)-2-(3-tert-butyl-1-phenyl-1H-pyrazol-5-ylamino)-N’-(4-chlorobenzylidene)acetohydrazide (4f), were evaluated to determine their in vivo anti-hyperalgesic profiles in carrageenan-induced thermal hypernociception model in rats. Both compounds showed anti-inflammatory and antinociceptive properties comparable to SB-203580 used as a standard drug, by oral route at a dose of 100 µmol/kg. This bioprofile is correlated with the ability of NAH derivatives (4a) and (4f) suppressing TNF-α levels in vivo by 57.3 and 55.8%, respectively." @default.
• W2010385215 created "2016-06-24" @default.
• W2010385215 creator A5031324853 @default.
• W2010385215 creator A5032620927 @default.
• W2010385215 creator A5045459148 @default.
• W2010385215 creator A5072208746 @default.
• W2010385215 creator A5072721136 @default.
• W2010385215 creator A5076822552 @default.
• W2010385215 creator A5078236570 @default.
• W2010385215 creator A5091866200 @default.
• W2010385215 date "2012-10-08" @default.
• W2010385215 modified "2023-10-14" @default.
• W2010385215 title "Discovery of Novel Orally Active Anti-Inflammatory N-Phenylpyrazolyl-N-Glycinyl-Hydrazone Derivatives That Inhibit TNF-α Production" @default.
• W2010385215 cites W1501675811 @default.
• W2010385215 cites W1970402936 @default.
• W2010385215 cites W1976798002 @default.
• W2010385215 cites W2013023341 @default.
• W2010385215 cites W2023639069 @default.
• W2010385215 cites W2025830067 @default.
• W2010385215 cites W2031170161 @default.
• W2010385215 cites W2032731042 @default.
• W2010385215 cites W2034657358 @default.
• W2010385215 cites W2038773696 @default.
• W2010385215 cites W2043389111 @default.
• W2010385215 cites W2072380594 @default.
• W2010385215 cites W2082594472 @default.
• W2010385215 cites W2083908345 @default.
• W2010385215 cites W2096305848 @default.
• W2010385215 cites W2109169089 @default.
• W2010385215 cites W2114918609 @default.
• W2010385215 cites W2115556861 @default.
• W2010385215 cites W2131882149 @default.
• W2010385215 cites W2135133228 @default.
• W2010385215 cites W2138510065 @default.
• W2010385215 cites W2144831969 @default.
• W2010385215 cites W2161897582 @default.
• W2010385215 cites W2166393142 @default.
• W2010385215 doi "https://doi.org/10.1371/journal.pone.0046925" @default.
• W2010385215 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3466213" @default.
• W2010385215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23056531" @default.
• W2010385215 hasPublicationYear "2012" @default.
• W2010385215 type Work @default.
• W2010385215 sameAs 2010385215 @default.
• W2010385215 citedByCount "21" @default.
• W2010385215 countsByYear W20103852152013 @default.
• W2010385215 countsByYear W20103852152014 @default.
• W2010385215 countsByYear W20103852152015 @default.
• W2010385215 countsByYear W20103852152016 @default.
• W2010385215 countsByYear W20103852152017 @default.
• W2010385215 countsByYear W20103852152018 @default.
• W2010385215 countsByYear W20103852152022 @default.
• W2010385215 countsByYear W20103852152023 @default.
• W2010385215 crossrefType "journal-article" @default.
• W2010385215 hasAuthorship W2010385215A5031324853 @default.
• W2010385215 hasAuthorship W2010385215A5032620927 @default.
• W2010385215 hasAuthorship W2010385215A5045459148 @default.
• W2010385215 hasAuthorship W2010385215A5072208746 @default.
• W2010385215 hasAuthorship W2010385215A5072721136 @default.
• W2010385215 hasAuthorship W2010385215A5076822552 @default.
• W2010385215 hasAuthorship W2010385215A5078236570 @default.
• W2010385215 hasAuthorship W2010385215A5091866200 @default.
• W2010385215 hasBestOaLocation W20103852151 @default.
• W2010385215 hasConcept C126322002 @default.
• W2010385215 hasConcept C150903083 @default.
• W2010385215 hasConcept C17991360 @default.
• W2010385215 hasConcept C184235292 @default.
• W2010385215 hasConcept C185592680 @default.
• W2010385215 hasConcept C202751555 @default.
• W2010385215 hasConcept C207001950 @default.
• W2010385215 hasConcept C2780349576 @default.
• W2010385215 hasConcept C2781227287 @default.
• W2010385215 hasConcept C51551487 @default.
• W2010385215 hasConcept C55493867 @default.
• W2010385215 hasConcept C57074206 @default.
• W2010385215 hasConcept C71240020 @default.
• W2010385215 hasConcept C71924100 @default.
• W2010385215 hasConcept C86803240 @default.
• W2010385215 hasConcept C98274493 @default.
• W2010385215 hasConceptScore W2010385215C126322002 @default.
• W2010385215 hasConceptScore W2010385215C150903083 @default.
• W2010385215 hasConceptScore W2010385215C17991360 @default.
• W2010385215 hasConceptScore W2010385215C184235292 @default.
• W2010385215 hasConceptScore W2010385215C185592680 @default.
• W2010385215 hasConceptScore W2010385215C202751555 @default.
• W2010385215 hasConceptScore W2010385215C207001950 @default.
• W2010385215 hasConceptScore W2010385215C2780349576 @default.
• W2010385215 hasConceptScore W2010385215C2781227287 @default.
• W2010385215 hasConceptScore W2010385215C51551487 @default.
• W2010385215 hasConceptScore W2010385215C55493867 @default.
• W2010385215 hasConceptScore W2010385215C57074206 @default.
• W2010385215 hasConceptScore W2010385215C71240020 @default.
• W2010385215 hasConceptScore W2010385215C71924100 @default.
• W2010385215 hasConceptScore W2010385215C86803240 @default.
• W2010385215 hasConceptScore W2010385215C98274493 @default.
• W2010385215 hasIssue "10" @default.
• W2010385215 hasLocation W20103852151 @default.
• W2010385215 hasLocation W20103852152 @default.
• W2010385215 hasLocation W20103852153 @default.

• next