FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010385231> ?p ?o ?g. }

• W2010385231 endingPage "536" @default.
• W2010385231 startingPage "529" @default.
• W2010385231 abstract "Background Vernal keratoconjunctivitis (VKC) is a severe though transient form of ocular allergy, predominant in young males, which requires careful management. Corticosteroids are effective but also cause serious topical side-effects in the eye, such as glaucoma and cataracts. The safer, mast cell stabilizing anti-inflammatories (commonly sodium cromoglycate) therefore have an important role. This parallel group study compared efficacy, tolerability and safety of sodium cromoglycate 2% with nedocromil sodium 2%, administered as one drop per eye four times daily for a period of 5 months. Methods Children aged 4–17 years, with a diagnosis of mostly limbal VKC in the last 12 months, entered a 2-week baseline during which they used only artificial tears, and were then randomized to treatment, in groups of 18, on an investigator single-masked basis. Daily symptom diary cards were kept by patients/guardians, and VKC was assessed by the clinician at approximately monthly intervals. Dexamethasone was provided for rescue control of severe symptoms, if needed. Results A total of 34 patients completed the study.Both trial treatments produced rapid improvements and many ocular signs and symptoms, including Trantas' dots, chemosis, itching, soreness and sticky discharge, were fully controlled by the end of the study. However, nedocromil sodium took effect more quickly, with a significant reduction compared to sodium cromoglycate for itching, grittiness, hyperaemia and keratitis within 6 weeks. In addition, nedocromil sodium was the more efficacious overall (significant vs sodium cromoglycate for hyperaemia, keratitis, papillae and pannus at 22 weeks). Both treatments were well tolerated and without serious adverse effects. Final opinions favoured nedocromil sodium, with full control of VKC recorded for 94% (patient opinion) and 100% (clinician opinion) of this treatment group, compared with 29% and 0%, respectively, in the sodium cromoglycate group. Conclusions Nedocromil sodium 2% eye drops is significantly more effective than sodium cromoglycate for treatment of VKC." @default.
• W2010385231 created "2016-06-24" @default.
• W2010385231 creator A5006803708 @default.
• W2010385231 creator A5045704818 @default.
• W2010385231 creator A5069821277 @default.
• W2010385231 date "1999-04-01" @default.
• W2010385231 modified "2023-09-23" @default.
• W2010385231 title "Nedocromil sodium eye drops are more effective than sodium cromoglycate eye drops for the long-term management of vernal keratoconjunctivitis" @default.
• W2010385231 cites W1819933654 @default.
• W2010385231 cites W1974844178 @default.
• W2010385231 cites W1984968537 @default.
• W2010385231 cites W1988512560 @default.
• W2010385231 cites W1990250264 @default.
• W2010385231 cites W1990593557 @default.
• W2010385231 cites W2001734185 @default.
• W2010385231 cites W2002850352 @default.
• W2010385231 cites W2004047181 @default.
• W2010385231 cites W2014557893 @default.
• W2010385231 cites W2016801684 @default.
• W2010385231 cites W2017014849 @default.
• W2010385231 cites W2019642401 @default.
• W2010385231 cites W2021349634 @default.
• W2010385231 cites W2024962352 @default.
• W2010385231 cites W2030209842 @default.
• W2010385231 cites W2033959129 @default.
• W2010385231 cites W2034073485 @default.
• W2010385231 cites W2038005530 @default.
• W2010385231 cites W2044704128 @default.
• W2010385231 cites W2059066094 @default.
• W2010385231 cites W2072080209 @default.
• W2010385231 cites W2079592327 @default.
• W2010385231 cites W2084383274 @default.
• W2010385231 cites W2086616049 @default.
• W2010385231 cites W2091765069 @default.
• W2010385231 cites W2096785196 @default.
• W2010385231 cites W2108300001 @default.
• W2010385231 cites W2109753932 @default.
• W2010385231 cites W2133813937 @default.
• W2010385231 cites W2136440182 @default.
• W2010385231 cites W2155418062 @default.
• W2010385231 cites W2165254265 @default.
• W2010385231 cites W4255531122 @default.
• W2010385231 cites W62181560 @default.
• W2010385231 doi "https://doi.org/10.1046/j.1365-2222.1999.00501.x" @default.
• W2010385231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10202368" @default.
• W2010385231 hasPublicationYear "1999" @default.
• W2010385231 type Work @default.
• W2010385231 sameAs 2010385231 @default.
• W2010385231 citedByCount "40" @default.
• W2010385231 countsByYear W20103852312012 @default.
• W2010385231 countsByYear W20103852312013 @default.
• W2010385231 countsByYear W20103852312014 @default.
• W2010385231 countsByYear W20103852312016 @default.
• W2010385231 countsByYear W20103852312017 @default.
• W2010385231 countsByYear W20103852312021 @default.
• W2010385231 countsByYear W20103852312022 @default.
• W2010385231 crossrefType "journal-article" @default.
• W2010385231 hasAuthorship W2010385231A5006803708 @default.
• W2010385231 hasAuthorship W2010385231A5045704818 @default.
• W2010385231 hasAuthorship W2010385231A5069821277 @default.
• W2010385231 hasConcept C118487528 @default.
• W2010385231 hasConcept C126322002 @default.
• W2010385231 hasConcept C142724271 @default.
• W2010385231 hasConcept C16005928 @default.
• W2010385231 hasConcept C197934379 @default.
• W2010385231 hasConcept C204787440 @default.
• W2010385231 hasConcept C27081682 @default.
• W2010385231 hasConcept C2776002719 @default.
• W2010385231 hasConcept C2776042228 @default.
• W2010385231 hasConcept C2776469317 @default.
• W2010385231 hasConcept C2777625524 @default.
• W2010385231 hasConcept C2778064476 @default.
• W2010385231 hasConcept C2778375690 @default.
• W2010385231 hasConcept C2779714575 @default.
• W2010385231 hasConcept C2779923671 @default.
• W2010385231 hasConcept C2780870513 @default.
• W2010385231 hasConcept C2910070530 @default.
• W2010385231 hasConcept C42219234 @default.
• W2010385231 hasConcept C71924100 @default.
• W2010385231 hasConceptScore W2010385231C118487528 @default.
• W2010385231 hasConceptScore W2010385231C126322002 @default.
• W2010385231 hasConceptScore W2010385231C142724271 @default.
• W2010385231 hasConceptScore W2010385231C16005928 @default.
• W2010385231 hasConceptScore W2010385231C197934379 @default.
• W2010385231 hasConceptScore W2010385231C204787440 @default.
• W2010385231 hasConceptScore W2010385231C27081682 @default.
• W2010385231 hasConceptScore W2010385231C2776002719 @default.
• W2010385231 hasConceptScore W2010385231C2776042228 @default.
• W2010385231 hasConceptScore W2010385231C2776469317 @default.
• W2010385231 hasConceptScore W2010385231C2777625524 @default.
• W2010385231 hasConceptScore W2010385231C2778064476 @default.
• W2010385231 hasConceptScore W2010385231C2778375690 @default.
• W2010385231 hasConceptScore W2010385231C2779714575 @default.
• W2010385231 hasConceptScore W2010385231C2779923671 @default.
• W2010385231 hasConceptScore W2010385231C2780870513 @default.
• W2010385231 hasConceptScore W2010385231C2910070530 @default.
• W2010385231 hasConceptScore W2010385231C42219234 @default.
• W2010385231 hasConceptScore W2010385231C71924100 @default.

• next