Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010388612> ?p ?o ?g. }
- W2010388612 endingPage "816" @default.
- W2010388612 startingPage "808" @default.
- W2010388612 abstract "Recombinant vectors based on adeno-associated virus (AAV) have been shown to stably express many genes in vivo without mounting immune responses to vectors or transgenes. Thus, AAV vectors have rapidly become the reagents of choice for therapeutic gene transfer. Yet one of the first translations of AAV gene therapy into humans unexpectedly resulted in only short-term expression of the therapeutic gene accompanied by transient but significant toxicity. Immune responses to the vector capsid were held accountable for these results, confirming that a detailed understanding of the interaction of AAV vectors with the immune system is of great importance for the safety and success of gene therapy applications. Most humans display naturally acquired immunity to AAV; circumventing neutralizing antibodies and memory T-cell responses is challenging, but not impossible. This review will evaluate the strategies that have been proposed to overcome such responses and summarize recent findings about the mechanisms and circumstances that lead to the activation of innate and adaptive immune responses to AAV vector components." @default.
- W2010388612 created "2016-06-24" @default.
- W2010388612 creator A5040562565 @default.
- W2010388612 creator A5070780289 @default.
- W2010388612 date "2008-04-03" @default.
- W2010388612 modified "2023-09-27" @default.
- W2010388612 title "Immunity to adeno-associated virus vectors in animals and humans: a continued challenge" @default.
- W2010388612 cites W1487084354 @default.
- W2010388612 cites W1505196125 @default.
- W2010388612 cites W1574987843 @default.
- W2010388612 cites W1593294300 @default.
- W2010388612 cites W1942870285 @default.
- W2010388612 cites W1965879742 @default.
- W2010388612 cites W1968015356 @default.
- W2010388612 cites W1968382713 @default.
- W2010388612 cites W1970138286 @default.
- W2010388612 cites W1972852573 @default.
- W2010388612 cites W1974877896 @default.
- W2010388612 cites W1975528602 @default.
- W2010388612 cites W1976329054 @default.
- W2010388612 cites W1977020173 @default.
- W2010388612 cites W1978519692 @default.
- W2010388612 cites W1980219722 @default.
- W2010388612 cites W1982698867 @default.
- W2010388612 cites W1988197108 @default.
- W2010388612 cites W1990993204 @default.
- W2010388612 cites W1993439119 @default.
- W2010388612 cites W1996875707 @default.
- W2010388612 cites W2002957246 @default.
- W2010388612 cites W2007261697 @default.
- W2010388612 cites W2008254103 @default.
- W2010388612 cites W2009310029 @default.
- W2010388612 cites W2012104351 @default.
- W2010388612 cites W2016197193 @default.
- W2010388612 cites W2017907569 @default.
- W2010388612 cites W2019868085 @default.
- W2010388612 cites W2021202438 @default.
- W2010388612 cites W2024397909 @default.
- W2010388612 cites W2029750163 @default.
- W2010388612 cites W2029884547 @default.
- W2010388612 cites W2034837473 @default.
- W2010388612 cites W2036704181 @default.
- W2010388612 cites W2041912408 @default.
- W2010388612 cites W2045292147 @default.
- W2010388612 cites W2045817726 @default.
- W2010388612 cites W2046841256 @default.
- W2010388612 cites W2047608515 @default.
- W2010388612 cites W2048487684 @default.
- W2010388612 cites W2048833964 @default.
- W2010388612 cites W2049309853 @default.
- W2010388612 cites W2050193680 @default.
- W2010388612 cites W2050796131 @default.
- W2010388612 cites W2052186992 @default.
- W2010388612 cites W2053849856 @default.
- W2010388612 cites W2065274386 @default.
- W2010388612 cites W2065451039 @default.
- W2010388612 cites W2066015597 @default.
- W2010388612 cites W2067204822 @default.
- W2010388612 cites W2070754430 @default.
- W2010388612 cites W2073545118 @default.
- W2010388612 cites W2073739917 @default.
- W2010388612 cites W2075227451 @default.
- W2010388612 cites W2076860206 @default.
- W2010388612 cites W2078035839 @default.
- W2010388612 cites W2080951809 @default.
- W2010388612 cites W2082549237 @default.
- W2010388612 cites W2086866768 @default.
- W2010388612 cites W2087427145 @default.
- W2010388612 cites W2088555526 @default.
- W2010388612 cites W2090849645 @default.
- W2010388612 cites W2091134968 @default.
- W2010388612 cites W2091177028 @default.
- W2010388612 cites W2098603564 @default.
- W2010388612 cites W2102111681 @default.
- W2010388612 cites W2105176806 @default.
- W2010388612 cites W2106378095 @default.
- W2010388612 cites W2113089955 @default.
- W2010388612 cites W2113444875 @default.
- W2010388612 cites W2115528849 @default.
- W2010388612 cites W2119164964 @default.
- W2010388612 cites W2123634260 @default.
- W2010388612 cites W2124799502 @default.
- W2010388612 cites W2137005738 @default.
- W2010388612 cites W2138084195 @default.
- W2010388612 cites W2140262802 @default.
- W2010388612 cites W2142499414 @default.
- W2010388612 cites W2145940587 @default.
- W2010388612 cites W2153867928 @default.
- W2010388612 cites W2155710930 @default.
- W2010388612 cites W2158480664 @default.
- W2010388612 cites W2158522626 @default.
- W2010388612 cites W2158749858 @default.
- W2010388612 cites W2168833276 @default.
- W2010388612 cites W2170490863 @default.
- W2010388612 cites W2174994066 @default.
- W2010388612 cites W2443947451 @default.
- W2010388612 cites W3075888328 @default.
- W2010388612 cites W4206826545 @default.