FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010389170> ?p ?o ?g. }

• W2010389170 endingPage "443" @default.
• W2010389170 startingPage "438" @default.
• W2010389170 abstract "Hypoxia has profound effects on blood vessel tone. Acute hypoxia causes pulmonary vasoconstriction and chronic hypoxia causes smooth muscle cell replication and extracellular matrix accumulation resulting in vessel wall remodeling. The cellular responses to hypoxia involve complex cell-cell interactions mediated by the release of growth factors, cytokines and biological messengers. We have reported that hypoxia increases the expression of a number of genes encoding vascular cell mitogens produced by endothelial cells: platelet-derived growth factor B (PDGF-B); endothelin-1 (ET-1); and vascular endothelial growth factor (VEGF). A 28-bp enhancer in the 5' upstream region of the VEGF gene mediates the expression of VEGF by endothelial cells under conditions of hypoxia. Hypoxia, however, has opposite effects on the vasodilator nitric oxide (NO); hypoxia suppresses both the transcriptional rate of the endothelial nitric oxide synthase gene and the stability of its mRNA. These endothelial-dependent processes would lead to vessel wall remodeling characteristic of a number of diseases from atherosclerosis to pulmonary hypertension. The smooth muscle cell also responds to hypoxia. It increases the transcriptional rate of the heme oxygenase gene-1 responsible for the breakdown of heme to carbon monoxide (CO) and biliverdin. CO is a vasodilator with properties similar to the well-studied molecule NO. CO suppresses the production of ET-1 and PDGF-B by endothelial cells. The regulated production of NO and CO under hypoxia, therefore, results in complex feedback loop interactions leading to altered smooth muscle cell growth in an autocrine and paracrine manner." @default.
• W2010389170 created "2016-06-24" @default.
• W2010389170 creator A5033304581 @default.
• W2010389170 creator A5044058475 @default.
• W2010389170 creator A5051609710 @default.
• W2010389170 creator A5074479505 @default.
• W2010389170 date "1997-02-01" @default.
• W2010389170 modified "2023-09-29" @default.
• W2010389170 title "Mechanisms by which oxygen regulates gene expression and cell-cell interaction in the vasculature" @default.
• W2010389170 cites W1501532586 @default.
• W2010389170 cites W1503667331 @default.
• W2010389170 cites W1536635467 @default.
• W2010389170 cites W1563036503 @default.
• W2010389170 cites W1586487499 @default.
• W2010389170 cites W1594872187 @default.
• W2010389170 cites W1721827275 @default.
• W2010389170 cites W1883906051 @default.
• W2010389170 cites W1981165639 @default.
• W2010389170 cites W1981749196 @default.
• W2010389170 cites W1988403143 @default.
• W2010389170 cites W1997031088 @default.
• W2010389170 cites W2014434817 @default.
• W2010389170 cites W2015344488 @default.
• W2010389170 cites W2016730049 @default.
• W2010389170 cites W2019615010 @default.
• W2010389170 cites W2035754770 @default.
• W2010389170 cites W2064951152 @default.
• W2010389170 cites W2067241300 @default.
• W2010389170 cites W2072839085 @default.
• W2010389170 cites W2087516645 @default.
• W2010389170 cites W2111496692 @default.
• W2010389170 cites W2313326603 @default.
• W2010389170 doi "https://doi.org/10.1038/ki.1997.58" @default.
• W2010389170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9027718" @default.
• W2010389170 hasPublicationYear "1997" @default.
• W2010389170 type Work @default.
• W2010389170 sameAs 2010389170 @default.
• W2010389170 citedByCount "108" @default.
• W2010389170 countsByYear W20103891702012 @default.
• W2010389170 countsByYear W20103891702013 @default.
• W2010389170 countsByYear W20103891702015 @default.
• W2010389170 countsByYear W20103891702016 @default.
• W2010389170 countsByYear W20103891702017 @default.
• W2010389170 countsByYear W20103891702020 @default.
• W2010389170 countsByYear W20103891702021 @default.
• W2010389170 countsByYear W20103891702022 @default.
• W2010389170 crossrefType "journal-article" @default.
• W2010389170 hasAuthorship W2010389170A5033304581 @default.
• W2010389170 hasAuthorship W2010389170A5044058475 @default.
• W2010389170 hasAuthorship W2010389170A5051609710 @default.
• W2010389170 hasAuthorship W2010389170A5074479505 @default.
• W2010389170 hasBestOaLocation W20103891701 @default.
• W2010389170 hasConcept C123012128 @default.
• W2010389170 hasConcept C126322002 @default.
• W2010389170 hasConcept C128240485 @default.
• W2010389170 hasConcept C134018914 @default.
• W2010389170 hasConcept C146285616 @default.
• W2010389170 hasConcept C15215337 @default.
• W2010389170 hasConcept C167734588 @default.
• W2010389170 hasConcept C170493617 @default.
• W2010389170 hasConcept C178790620 @default.
• W2010389170 hasConcept C181199279 @default.
• W2010389170 hasConcept C185592680 @default.
• W2010389170 hasConcept C202751555 @default.
• W2010389170 hasConcept C2776217839 @default.
• W2010389170 hasConcept C2776992346 @default.
• W2010389170 hasConcept C2777025900 @default.
• W2010389170 hasConcept C2779219270 @default.
• W2010389170 hasConcept C2779395532 @default.
• W2010389170 hasConcept C2992686903 @default.
• W2010389170 hasConcept C502942594 @default.
• W2010389170 hasConcept C519581460 @default.
• W2010389170 hasConcept C540031477 @default.
• W2010389170 hasConcept C55493867 @default.
• W2010389170 hasConcept C71924100 @default.
• W2010389170 hasConcept C7836513 @default.
• W2010389170 hasConcept C7876069 @default.
• W2010389170 hasConcept C86803240 @default.
• W2010389170 hasConcept C95444343 @default.
• W2010389170 hasConceptScore W2010389170C123012128 @default.
• W2010389170 hasConceptScore W2010389170C126322002 @default.
• W2010389170 hasConceptScore W2010389170C128240485 @default.
• W2010389170 hasConceptScore W2010389170C134018914 @default.
• W2010389170 hasConceptScore W2010389170C146285616 @default.
• W2010389170 hasConceptScore W2010389170C15215337 @default.
• W2010389170 hasConceptScore W2010389170C167734588 @default.
• W2010389170 hasConceptScore W2010389170C170493617 @default.
• W2010389170 hasConceptScore W2010389170C178790620 @default.
• W2010389170 hasConceptScore W2010389170C181199279 @default.
• W2010389170 hasConceptScore W2010389170C185592680 @default.
• W2010389170 hasConceptScore W2010389170C202751555 @default.
• W2010389170 hasConceptScore W2010389170C2776217839 @default.
• W2010389170 hasConceptScore W2010389170C2776992346 @default.
• W2010389170 hasConceptScore W2010389170C2777025900 @default.
• W2010389170 hasConceptScore W2010389170C2779219270 @default.
• W2010389170 hasConceptScore W2010389170C2779395532 @default.
• W2010389170 hasConceptScore W2010389170C2992686903 @default.
• W2010389170 hasConceptScore W2010389170C502942594 @default.

• next