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• W2010394501 abstract "Adverse reactions to food, i.e. food allergy and intolerance have gained considerable attention. This overview focuses on the diagnosis and management of IgE-mediated food allergy that is believed to be responsible for most immediate-type food-induced hypersensitivity reactions. Clinically, these reactions are characterised by a variety of signs and symptoms that occur within minutes or hours after consumption of the offending food. Reactions may be limited or more generalised with involvement of the skin, nose, eyes, and/or lungs. In more severe cases, cardiovascular symptoms including hypotension, shock, cardiac dysrhythmias and death can occur. In food-allergic individuals, IgE is produced against naturally occurring food components, primarily glycoproteins that usually retain their allergenicity after heating and/or proteolysis. While adults tend to be allergic to fish, crustaceans, peanuts and tree nuts, children tend to be allergic to cow's milk, egg white, wheat and soy more frequently. Emerging food allergens include tropical fruits, sesame seeds, psyllium, spices and condiments. These allergies frequently represent a cross-allergy to an allergen derived from another source, e.g. pollens or natural rubber latex. The evaluation of IgE-mediated food allergy relies on a careful history, physical examination, appropriate skin testing or in vitro testing with food extracts, and/or double blind, placebo-controlled food challenges. Avoidance remains the mainstay of therapy. However, allergens may be hidden and labelling can be non-precise or misleading, thereby severely hampering prevention. Patients with severe allergies should keep at hand an emergency kit with adrenaline, an antihistamine and an injectable rapid onset-of-action corticosteroid. At present there is no evidence to support the use of immunotherapy, except for research purposes. Production of hypoallergenic food is hampered by incomplete methods for assessing the allergenic potential of such novel foods." @default.
• W2010394501 created "2016-06-24" @default.
• W2010394501 creator A5005164429 @default.
• W2010394501 creator A5015844269 @default.
• W2010394501 date "2001-08-01" @default.
• W2010394501 modified "2023-10-13" @default.
• W2010394501 title "IGE-MEDIATED FOOD ALLERGY – EXTENSIVE REVIEW OF THE LITERATURE" @default.
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• W2010394501 doi "https://doi.org/10.1179/acb.2001.035" @default.
• W2010394501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11603253" @default.
• W2010394501 hasPublicationYear "2001" @default.
• W2010394501 type Work @default.

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